Ethyl 4,4,4-Trifluorobutyrate

[ Density]:
1.16 g/mL at 25 °C(lit.)

[ Boiling Point ]:
127 °C(lit.)

[ Molecular Formula ]:
C₆H₉F₃O₂

[ Molecular Weight ]:
170.13000

[ Flash Point ]:
92 °F

[ Exact Mass ]:
170.05500

[ PSA ]:
26.30000

[ LogP ]:
1.89200

[ Index of Refraction ]:
n20/D 1.3516(lit.)

[ Storage condition ]:
Flammables area

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[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H302-H312-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R10;R20/21/22;R36/37

[ Safety Phrases ]:
S16-S26-S36

[ RIDADR ]:
UN 3272 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2915900090

Precursor

DownStream

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Compounds Derived from 3-Halo-1, 1, 1-trifluoropropane1, 2. McBee E, et al.

J. Am. Chem. Soc. 72(11) , 5071-73, (1950)

J. Org. Chem. 60 , 5434, (1995)

Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2-methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methyl indol- 3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a potent, orally active antagonist of leukotrienes D4 and E4.

J. Med. Chem. 37 , 1282, (1994)

The continued exploration of a series of 3-(arylmethyl)-1H-indole-5-carboxamides by the introduction of fluorinated amide substituents has resulted in the discovery of 4-[[5-[((2R)-2-methyl-4,4,4-trif...

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