Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)
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Names
[ CAS No. ]:
3724-89-8
[ Name ]:
Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)
[Synonym ]:
Phosphocysteamine
Tsistafos
MFCD00038474
Cystaphos sodium salt
Tsistafos (cystafos)
Cystaphos
Cistaphos
S-(2-Aminoethyl) thiophosphate monosodium salt
EINECS 223-079-5
Cystafos
Chemical & Physical Properties
[ Density]:
1.597g/cm3
[ Boiling Point ]:
384.2ºC at 760mmHg
[ Melting Point ]:
220ºC (dec.)(lit.)
[ Molecular Formula ]:
C2H7NNaO3PS
[ Molecular Weight ]:
179.11000
[ Flash Point ]:
186.2ºC
[ Exact Mass ]:
178.97800
[ PSA ]:
121.49000
[ LogP ]:
0.90950
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TE6483500
- CHEMICAL NAME :
- Phosphorothioic acid, S-(2-aminoethyl) ester, monosodium salt
- CAS REGISTRY NUMBER :
- 3724-89-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C2-H7-N-O3-P-S.Na
- MOLECULAR WEIGHT :
- 179.12
- WISWESSER LINE NOTATION :
- Z2SPQO&O &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 555 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 505 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1433 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 806 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1003 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 358 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
22-36/37/38
[ Safety Phrases ]:
S26;S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
TE6483500
Articles
Pediatr. Res. 23(6) , 616-20, (1988)
Cysteamine (beta-mercaptoethylamine, MEA) is currently used to treat children with nephropathic cystinosis. In this study MEA was compared to phosphocysteamine (MEAP), a phosphorothioester that tastes...
Pediatr. Nephrol. 9(6) , 685-9, (1995)
Fifty-nine patients with cystinosis were treated with cysteamine or phosphocysteamine in the United Kingdom up to May 1990. Treatment was started at a median age of 3.2 years (range 0.6-24.8 years) an...
J. Inherit. Metab. Dis. 35(5) , 847-57, (2012)
Infantile neuronal ceroid lipofuscinosis (INCL) is a profoundly neurodegenerative disease of children caused by a deficiency in the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1). There is c...