2,2,2-trifluoroethanaminium chloride

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Names

[ CAS No. ]:
373-88-6

[ Name ]:
2,2,2-trifluoroethanaminium chloride

[Synonym ]:
2,2,2-Trifluoroethanamine hydrochloride
Ethylamine, 2,2,2-trifluoro-, hydrochloride (8CI)
EINECS 206-771-1
Ethanamine, 2,2,2-trifluoro-, hydrochloride (1:1)
2,2,2-trifluoroethanamine,hydrochloride
2,2,2-trifluoroethanaminium chloride
2,2,2-Trifluoroethanamine hydrochloride (1:1)
MFCD00012875
2,2,2-TrifluoroethylaMine Hydrochloride
TrifluorethylaminHCL

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
121.9ºC at 760 mmHg

[ Melting Point ]:
220-222 °C (subl.)(lit.)

[ Molecular Formula ]:
C2H5ClF3N

[ Molecular Weight ]:
135.516

[ Flash Point ]:
27.6ºC

[ Exact Mass ]:
135.006256

[ PSA ]:
26.02000

[ LogP ]:
2.00970

[ Index of Refraction ]:
1.3-1.302

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KS0250000
CHEMICAL NAME :
Ethylamine, trifluoro-, hydrochloride
CAS REGISTRY NUMBER :
373-88-6
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C2-H4-F3-N.Cl-H
MOLECULAR WEIGHT :
135.53
WISWESSER LINE NOTATION :
Z1XFFF &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
476 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
11FYAN "Fluorine Chemistry, Volume III. Biological Effects of Organic Fluorides," Simons, J.H., ed., New York, Academic Press, Inc., 1963 Volume(issue)/page/year: 3,81,1963

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;T: Toxic;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36/37-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
KS0250000

[ Packaging Group ]:
III

[ HS Code ]:
2921199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzylamine
  • trifluoroacetic acid
  • N-(2,2,2-trifluoroethyl)benzamide

DownStream

  • OPANAMIDE, 2-AMINO-N-(2,2,2-TRIFLUOROETHYL)-, HYDROCHLORIDE (1:1), (2S)-
  • 1-(2,2,2-trifluoroethyl)pyridin-4-one
  • {2-[3-(Trifluoromethyl)-1-cyclopropen-1-yl]ethyl}benzene
  • 1-Nonyl-3-(trifluoromethyl)cyclopropene
  • 2-diazo-1,1,1-trifluoroethane
  • 2-oxido-3,4-bis(trifluoromethyl)-1,2,5-oxadiazol-2-ium
  • N-(2,2,2-trifluoroethyl)pyridin-2-amine
  • Urea,N-(2,2,2-trifluoroethyl)-
  • 3-methyl-1-(2,2,2-trifluoroethyl)urea
  • Acetamide, 2,2,2-trifluoro-N-(2,2,2-trifluoroethyl)-

Customs

[ HS Code ]: 2921199090

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Aqueous in situ derivatization of carboxylic acids by an ionic carbodiimide and 2,2,2-trifluoroethylamine for electron-capture detection.

J. Chromatogr. A. 1145(1-2) , 241-5, (2007)

We report a technique for the rapid, room temperature derivatization of aqueous carboxylic acids to the corresponding 2,2,2-trifluoroethylamide derivative. 3-Ethyl-1-[3-(dimethylamino)propyl]carbodiim...


More Articles

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