4-Methoxy-7H-pyrimido[4,5-b][1,4]thiazin-6-amine

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Names

[ CAS No. ]:
37497-00-0

[ Name ]:
4-Methoxy-7H-pyrimido[4,5-b][1,4]thiazin-6-amine

[Synonym ]:
4-Methoxy-7H-pyrimido(4,5-b)(1,4)thiazin-6-amine
Thomizin-Base
4-Methoxy-6-aminopyrimido<4,5-b>-1,4-thiazin
4-Methoxy-6-aminopyrimido<4,5-b>(1,4)thiazine
7H-Pyrimido(4,5-b)(1,4)thiazine,6-amino-4-methoxy
6-Amino-4-methoxy-7H-pyrimido(4,5-b)(1,4)thiazine
4-methoxy-7H-pyrimido[4,5-b][1,4]thiazin-6-ylamine

Chemical & Physical Properties

[ Density]:
1.64g/cm3

[ Boiling Point ]:
456.8ºC at 760 mmHg

[ Molecular Formula ]:
C7H8N4OS

[ Molecular Weight ]:
196.23000

[ Flash Point ]:
230.1ºC

[ Exact Mass ]:
196.04200

[ PSA ]:
98.69000

[ LogP ]:
0.71550

[ Index of Refraction ]:
1.774

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW7864000
CHEMICAL NAME :
7H-Pyrimido(4,5-b)(1,4)thiazine, 6-amino-4-methoxy-
CAS REGISTRY NUMBER :
37497-00-0
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H8-N4-O-S
MOLECULAR WEIGHT :
196.25
WISWESSER LINE NOTATION :
T66 BN DN GN JS IHJ EO1 HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1205,1977

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-chloroacetonitrile
  • 5-amino-6-methoxy-1H-pyrimidine-4-thione

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 4-Methoxy-7H-pyrimido[4,5-b][1,4]thiazin-6-amine hydrochloride (1:1)
  • 4-(4-methoxy-7H-pyrimido[4,5-b][1,4]thiazin-6-yl)aniline
  • 4-methylsulfanyl-7H-pyrimido[4,5-b][1,4]thiazin-6-amine
  • (4-hydrazinyl-7H-pyrimido[4,5-b][1,4]thiazin-6-yl)hydrazine
  • (4-methylsulfanyl-7H-pyrimido[4,5-b][1,4]thiazin-6-yl)hydrazine
  • 4-methoxy-5H-pyrimido[4,5-b][1,4]thiazin-6-one
  • 5-Bromo-4-methoxy-2-(4-{pyrazolo[1,5-a]pyrimidin-5-yloxy}piperidin-1-yl)pyrimidine
  • 3-[(1-{1H-pyrazolo[3,4-d]pyrimidin-4-yl}azetidin-3-yl)methoxy]pyridine
  • N-[1-(3-bromo-5-chloropyridin-2-yl)piperidin-4-yl]cyclobutanecarboxamide
  • 6-Bromo-2-[3-(pyridin-2-yl)pyrrolidin-1-yl]-1,3-benzothiazole
  • 2-[4-(1-benzothiophen-4-yl)piperazin-1-yl]-N-(propan-2-yl)acetamide
  • 2-{4-[6-(1H-pyrazol-1-yl)pyridin-2-yl]piperazin-1-yl}quinoxaline
  • 2-{3-[(pyrazin-2-yloxy)methyl]piperidin-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide
  • 4-[7-(2,3-dimethoxybenzoyl)-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-3-yl]-1-methyl-1H-pyrazole
  • 1-[1-(1,3-Benzoxazol-2-yl)piperidin-4-yl]-3-phenylimidazolidine-2,4-dione
  • 4-[7-(2-methoxy-5-methylbenzenesulfonyl)-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-3-yl]-1-methyl-1H-pyrazole
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