Varenicline Tartrate

Suppliers

Names

[ Name ]:
Varenicline Tartrate

[Synonym ]:
7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate Champix
(2R,3R)-3-carboxy-2,3-dihydroxypropanoate de (1R,12S)-5,8-diaza-14-azoniatétracyclo[10.3.1.0.0]hexadéca-2(11),3,5,7,9-pentaène
Chantix
(1R,12S)-5,8-Diaza-14-azoniatetracyclo[10.3.1.0.0]hexadeca-2(11),3,5,7,9-pentaene (2R,3R)-3-carboxy-2,3-dihydroxypropanoate
(1R,12S)-5,8-Diaza-14-azoniatetracyclo[10.3.1.0.0]hexadeca-2(11),3,5,7,9-pentaen-(2R,3R)-3-carboxy-2,3-dihydroxypropanoat
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (6R,10S)-7,8,9,10-tetrahydro-6,10-methano-6H-azepino[4,5-g]quinoxaline (1:1)
Champix
Varenicline tartrate

Chemical & Physical Properties

[ Boiling Point ]:
400.6ºC at 760 mmHg

[ Melting Point ]:
206-208ºC

[ Molecular Formula ]:
C₁₇H₁₉N₃O₆

[ Molecular Weight ]:
361.35

[ PSA ]:
23.79000

[ LogP ]:
4.49528

[ Storage condition ]:
Desiccate at RT

[ Water Solubility ]:
DMSO: >5mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
Xn,N,T,F

[ Risk Phrases ]:
22-50-39/23/24/25-23/24/25-11

[ Safety Phrases ]:
22-57-45-36/37-16-7

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Concurrent access to nicotine and sucrose in rats.

Psychopharmacol. Ser. 232(8) , 1451-60, (2015)

Animal models that allow concurrent access to drug and nondrug reinforcers provide unique insight into the etiology, maintenance, and treatment of drug use.We sought to develop and utilize a concurren...

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology 99 , 142-55, (2015)

Chronic treatment with nicotine is known to increase the α4β2-nAChR sites in brain, to decrease α6β2-nAChR sites and to have minimal effect on α3β4-and α7-nAChR populations. Varenicline is now used as...

Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization.

Alcohol. Clin. Exp. Res. 38(12) , 3033-42, (2015)

Varenicline, a partial nicotinic acetylcholine receptor (nAChR) agonist, is a promising new drug for the treatment of alcohol (ethanol [EtOH]) dependence. Varenicline has been approved by the Food and...