Clofoctol

Suppliers

Names

[ CAS No. ]:
37693-01-9

[ Name ]:
Clofoctol

[Synonym ]:
EINECS 253-632-6
2-(2,4-Dichlorobenzyl)-4-(1,1,3,3-tetramethylbutyl)phenol
Clofoctolum
Octofene
clofoctol

Chemical & Physical Properties

[ Density]:
1.127 g/cm3

[ Boiling Point ]:
447.7ºC at 760 mmHg

[ Melting Point ]:
78°

[ Molecular Formula ]:
C21H26Cl2O

[ Molecular Weight ]:
365.33700

[ Flash Point ]:
160.4ºC

[ Exact Mass ]:
364.13600

[ PSA ]:
20.23000

[ LogP ]:
7.00360

[ Index of Refraction ]:
1.555

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL0533000
CHEMICAL NAME :
Phenol, 2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethyl butyl)-
CAS REGISTRY NUMBER :
37693-01-9
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H26-Cl2-O
MOLECULAR WEIGHT :
365.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3830852

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
SL0533000

Articles

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.

Br. J. Pharmacol. 171(19) , 4478-89, (2014)

Finding new indications for existing drugs, also known as drug repositioning or repurposing, is a powerful approach to accelerate drug discovery and development. The unfolded protein response pathways...

A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay.

Drugs Exp. Clin. Res. 14(1) , 39-43, (1988)

A microbiological assay was undertaken to measure the amounts of clofoctol in human plasma and pulmonary tissue, and to investigate its pharmacokinetics. Clofoctol was extracted from samples using eth...

Alteration of membrane permeability in Bacillus subtilis by clofoctol.

J. Gen. Microbiol. 129(4) , 1089-95, (1983)

When Bacillus subtilis was treated with a bacteriostatic concentration of clofoctol [2-(2,4-dichlorobenzyl)-4-(tetramethyl-1,1,3,3-butyl)phenol], UV-absorbing material was released. Electron micrograp...


More Articles

Related Compounds

  • 2-[4-(Difluoromethyl)thiophen-3-yl]-5-methylpiperidin-3-amine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide