Sulfamethomidine

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Names

[ CAS No. ]:
3772-76-7

[ Name ]:
Sulfamethomidine

[Synonym ]:
Methofazine
N1-<6-Methoxy-2-methyl-pyrimidinyl-(4)>-sulfanilamid
4-amino-N-(6-methoxy-2-methyl-pyrimidin-4-yl)-benzenesulfonamide
Duroprocin
Sulfametomidina [INN-Spanish]
Sulfamethomidine
Sulfametomidine
Methofadin
Sulfanilsaeure-(6-methoxy-2-methyl-pyrimidin-4-ylamid)
sulfanilic acid-(6-methoxy-2-methyl-pyrimidin-4-ylamide)
SA 412
EINECS 223-219-5
Sulfametomidinum [INN-Latin]
Solfametomidina [DCIT]
4-<4-Amino-benzolsulfonylamino>-6-methoxy-2-methyl-pyrimidin
Sulfamethomidin

Chemical & Physical Properties

[ Density]:
1.418g/cm3

[ Boiling Point ]:
501.6ºC at 760mmHg

[ Molecular Formula ]:
C12H14N4O3S

[ Molecular Weight ]:
294.33000

[ Flash Point ]:
257.2ºC

[ Exact Mass ]:
294.07900

[ PSA ]:
115.58000

[ LogP ]:
2.91160

[ Index of Refraction ]:
1.633

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WP0110000
CHEMICAL NAME :
Sulfanilamide, N(sup 1)-(6-methoxy-2-methyl-4-pyrimidinyl)-
CAS REGISTRY NUMBER :
3772-76-7
BEILSTEIN REFERENCE NO. :
0284949
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H14-N4-O3-S
MOLECULAR WEIGHT :
294.36
WISWESSER LINE NOTATION :
T6N CNJ B1 DO1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3 gm/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,17,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,7,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3 gm/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,17,1973

Safety Information

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Pyrimidinamine, 6-methoxy-2-methyl- (9CI)
  • 4-Acetamidobenzenesulfonyl chloride
  • N-[4-[(6-methoxy-2-methylpyrimidin-4-yl)sulfamoyl]phenyl]acetamide
  • 4,6-Dichloro-2-methylpyrimidine
  • 4-Acetamidobenzenesulfonamide

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Related Compounds

  • (S)-2-(2-Amino-3-methylbutanamido)acetic acid trifluoroacetate
  • 7-Methoxy-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phthalazin-1(2H)-one
  • 5-Fluoro-1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-1,2,3-triazole
  • rel-3-((1R,3S)-1-(2-Aminoethoxy)-3-hydroxy-7-azaspiro[3.5]nonane-7-carbonyl)-1-methylpyridin-2(1H)-one
  • Methyl 3-((4-(3-methoxybenzyl)pyridin-2-yl)amino)-2-methylbenzoate
  • Methyl 6-phenyl-2-(p-tolyl)-2,3,4,5-tetrahydropyridazine-3-carboxylate
  • Methyl 4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2-dihydropyrimidine-5-carboxylate
  • (2S,3R,4R,5S,6R)-3-Amino-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2,4,5-triol
  • (3S,9aS)-3-(3-Methoxyphenyl)octahydro-2H-quinolizine
  • 2-(2-Bromophenyl)-4H-benzo[4,5]imidazo[2,1-b][1,3]thiazin-4-one
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