Morsuximide

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Names

[ CAS No. ]:
3780-72-1

[ Name ]:
Morsuximide

[Synonym ]:
Morsuximidum [INN-Latin]
3-methyl-1-morpholin-4-ylmethyl-3-phenyl-pyrrolidine-2,5-dione
Morpholep
Succinimide,2-methyl-N-(morpholinomethyl)-2-phenyl
S 210
Morsuximida [INN-Spanish]
2-Phenyl-2-methyl-N-morpholinomethyl-succinimid
Morfolep
Perlepsin
1-Morpholinomethyl-3-methyl-3-phenylpyrrolidin-2,5-dion
Morsuximide
2-Methyl-N-(morpholinomethyl)-2-phenylsuccinimide

Chemical & Physical Properties

[ Density]:
1.213g/cm3

[ Boiling Point ]:
473ºC at 760mmHg

[ Molecular Formula ]:
C16H20N2O3

[ Molecular Weight ]:
288.34200

[ Flash Point ]:
239.9ºC

[ Exact Mass ]:
288.14700

[ PSA ]:
49.85000

[ LogP ]:
0.86870

[ Index of Refraction ]:
1.567

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WN3150000
CHEMICAL NAME :
Succinimide, 2-methyl-N-(morpholinomethyl)-2-phenyl-
CAS REGISTRY NUMBER :
3780-72-1
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C16-H20-N2-O3
MOLECULAR WEIGHT :
288.38
WISWESSER LINE NOTATION :
T6N DOTJ A1- BT5VNVTJ D1 DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,266,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Behavioral - analgesia
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 44,22,1981

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • morpholine
  • Formaldehyde
  • 2-methyl-2-phenylsuccinimide
  • (+/-)-2-Methyl-2-phenylbutanedioic acid

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-(2,6-Difluoro-4-nitrophenyl)-isoindole-1,3-dione
  • 1-(2,6-Difluoro-4-nitrophenyl)-1H-imidazole
  • [1-(2,6-Difluoro-4-nitro-phenyl)-1h-imidazol-4-yl]-methanol
  • 1-(4-azido-2-fluorophenyl)-1H-pyrazole
  • 1-(4-amino-2-fluorophenyl)-4-(tert-butyldimethylsilanyloxymethyl)-1H-imidazole
  • 2-(4-Amino-2,6-difluoro-phenyl)-isoindole-1,3-dione
  • 1-(Piperidin-4-yloxy)propan-2-one
  • (E)-3-bromo-3,3-difluoro-1-nitroprop-1-ene
  • US9796704, Entry 148
  • [4-(2-Aminopyridin-4-yloxy)-3-fluorophenyl]carbamic acid benzyl ester
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