(-)-Dexamethasone Acid

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Names

[ CAS No. ]:
37927-01-8

[ Name ]:
(-)-Dexamethasone Acid

[Synonym ]:
(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.351g/cm3

[ Boiling Point ]:
566.865ºC at 760 mmHg

[ Melting Point ]:
274-277ºC

[ Molecular Formula ]:
C21H27FO5

[ Molecular Weight ]:
378.43400

[ Flash Point ]:
296.63ºC

[ Exact Mass ]:
378.18400

[ PSA ]:
94.83000

[ LogP ]:
2.41890

[ Index of Refraction ]:
1.598

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Dexamethasone
  • 11β,17α-dihydroxy-9α-fluoro-16α-methyl-3,20-dioxo-1,4-pregnadien-21-al

DownStream

  • (11β,16α,17α,11'β,16'α,17'α)-N,N'-(Disulfanediyldi-2,1-ethanediyl )bis(9-fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-1 7-carboxamide)
  • (11β,16α,17α)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxo-N-(2-sulfa nylethyl)androsta-1,4-diene-17-carboxamide

Related Compounds

  • Dexamethasone pivalate
  • Octanethioic acid S-propyl ester
  • Hexanethioic acid S-decyl ester
  • Thiopropionic acid S-undecyl ester
  • trisporic acid
  • Benzenesulfonic acid, 3,3-methylenebis2,4(or 4,6)-dihydroxyphenyleneazobis-, potassium sodium salt
  • N-(4-chlorophenyl)-2-(7-(3-methoxyphenyl)-2-methyl-4-oxothiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
  • 2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)-N-phenylacetamide
  • N-(2-fluorophenyl)-2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
  • N-(3-fluorophenyl)-2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
  • N-(4-fluorophenyl)-2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
  • N-(2,4-difluorophenyl)-2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
  • 2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)-N-((tetrahydrofuran-2-yl)methyl)acetamide
  • N-(3-chlorophenyl)-2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
  • N-(4-chlorophenyl)-2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
  • N-(3-chloro-4-methylphenyl)-2-(2-methyl-4-oxo-7-(thiophen-2-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
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