Tenofovir alafenamide

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Names

[ CAS No. ]:
379270-37-8

[ Name ]:
Tenofovir alafenamide

[Synonym ]:
Isopropyl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate
GS7340
Sp-Tenofovir-phosphonamidate,phenyl,L-alanine isopropyl ester
L-Alanine, N-[(S)-[(1S)-[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
Tenofovir alafenamide
GS-7340

Chemical & Physical Properties

[ Density]:
1.39±0.1 g/cm3

[ Boiling Point ]:
640.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H29N6O5P

[ Molecular Weight ]:
476.466

[ Flash Point ]:
341.1±34.3 °C

[ Exact Mass ]:
476.193695

[ PSA ]:
153.29000

[ LogP ]:
2.20

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Water Solubility ]:
Practically insoluble (0.04 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • H-Ala-OiPr
  • [[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, Monophenylester
  • Tenofovir
  • D-Alanine isopropyl ester hydrochloride
  • Triphenyl phosphite
  • Phenol

DownStream

Related Compounds

  • Tenofovir alafenamide
  • TENOFOVIR ALAFENAMIDE
  • Tenofovir alafenamide fumarate
  • Tenofovir alafenamide fumarate
  • Tenofovir Alafenamide PMPA Impurity
  • Tenofovir Related Compound 14
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methyl-3-phenyl-7-(thiophen-2-ylmethyl)-2,7-diazaspiro[3.5]nonan-1-one
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 4-bromo-5-(propoxymethyl)-1-propyl-1H-pyrazole
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 2-[(Dimethylamino)methylene]succinimide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde