3-trifluoromethylpyridine

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Names

[ CAS No. ]:
3796-23-4

[ Name ]:
3-trifluoromethylpyridine

[Synonym ]:
MFCD00100032
3-(Trifluoromethyl)pyridine
Pyridine, 3-(trifluoromethyl)-
EINECS 223-268-2
3-trifluoromethylpyridine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
127.8±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C6H4F3N

[ Molecular Weight ]:
147.098

[ Flash Point ]:
31.1±25.9 °C

[ Exact Mass ]:
147.029587

[ PSA ]:
12.89000

[ LogP ]:
1.70

[ Vapour Pressure ]:
13.3±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.419

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H300-H315-H319-H335

[ Precautionary Statements ]:
P261-P264-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T: Toxic;Xi: Irritant;F: Flammable;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S26-S45-S37

[ RIDADR ]:
UN 1992 3/PG 3

[ WGK Germany ]:
2

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Iodopyridine
  • (Trifluoromethyl)trimethylsilane
  • Nicotinic acid
  • copper(1+),trifluoromethane
  • 2-Chloro-6-trifluoromethylpyridine
  • Tributyl(trifluoromethyl)stannane
  • 3-Bromopyridine
  • 3-Pyridylboronic acid
  • Pyrrole
  • 2,2,4,4-Tetra(trifluoromethyl)-1,3-dithiacyclobutane

DownStream

  • 3-(Trifluoromethyl)pyridine-2-carboxylic acid
  • Methyl 3-(trifluoromethyl)picolinate
  • 2-Chloro-6-trifluoromethylpyridine
  • dimethyl 8-(trifluoromethyl)indolizine-1,2-dicarboxylate

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Olfactory and hepatic changes following inhalation of 3-trifluoromethyl pyridine in rats.

Toxicology 50(1) , 57-68, (1988)

Rats exposed by inhalation to 3-trifluoromethylpyridine (3-FMP) for 10, 30 or 90 days showed an unusual response in the nasal passages. Focal histological change including reduction in the number of c...

Olfactory and hepatic changes following a single inhalation exposure of 3-trifluoromethyl pyridine in rats: concentration and temporal aspects.

Toxicology 62(1) , 35-51, (1990)

The effects of a single exposure to 3-trifluoromethyl pyridine (3FMP), were investigated in two studies. In the first study, rats were exposed nose only to 0, 50 or 800 ppm 3FMP for periods of 15 min ...

The accumulation and metabolism of 3-trifluoromethylpyridine by rat olfactory and hepatic tissues.

Toxicology 72(1) , 61-75, (1992)

The accumulation of [methyl-14C]3-trifluoromethylpyridine (14C-3-FMP) by rat olfactory and hepatic tissue in vivo and in vitro has been investigated. 14C-3-FMP accumulates rapidly and selectively in b...


More Articles

Related Compounds

  • 3-trifluoromethylpyridine N-oxide
  • 2-Bromo-3-trifluoromethylpyridine
  • 2-Bromo-3-trifluoromethylpyridine
  • 2-Cyano-3-trifluoromethylpyridine
  • 2-Bromo-3-trifluoromethylpyridine
  • 6-Bromo-3-trifluoromethylpyridine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-[1-[2-(trifluoromethyl)benzoyl]piperidin-4-yl]-4aH-quinazoline-2,4-dione
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide