4-Trifluoromethylpyridine

Suppliers

Names

[ Name ]:
4-Trifluoromethylpyridine

[Synonym ]:
Pyridine, 4-(trifluoromethyl)-
4-trifluoromethyl-pyridine
p-trifluoromethylpyridine
4-CF3-C5H4N
para-trifluoromethylpyridine
4-(Trifluoromethyl)pyridine
Pyridine,4-trifluoromethyl
4-CF3-pyridine
4-Trifluoromethylpyridine
Pyridine, 4-trifluoromethyl-
trifluoromethylpyridine
MFCD00153289

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
141.7±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₄F₃N

[ Molecular Weight ]:
147.098

[ Flash Point ]:
39.5±25.9 °C

[ Exact Mass ]:
147.029587

[ PSA ]:
12.89000

[ LogP ]:
1.30

[ Vapour Pressure ]:
7.2±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.419

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H315-H319-H335

[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;Xi:Irritant;

[ Risk Phrases ]:
R11;R36/37/38

[ Safety Phrases ]:
S16-S26-S36-S37/60

[ RIDADR ]:
UN 1993 3/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Iodopyridine
(Trifluoromethyl)trimethylsilane
3-hydroxy-3-(trifluoromethyl)pentanedial
Isonicotinic acid
4-Hydroxy-4-(trifluoromethyl)hepta-1,6-diene
Iodotrifluoromethane
Pyridine-4-boronic acid
copper(1+),trifluoromethane
4-Bromo-pyridine HCl
Pyridine

DownStream

1-(4-(Trifluoromethyl)pyridin-2-yl)ethanone
4-(Trifluoromethyl)pyridine 1-oxide
4-Picoline
2-Chloro-4-(trifluoromethyl)pyridine
3-Iodo-4-(trifluoromethyl)-pyridine
2-Iodo-4-trifluoromethyl-pyridine
4-(Trifluoromethyl)nicotinic acid

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Copper-mediated trifluoromethylation of heteroaromatic compounds by trifluoromethyl sulfonium salts.

Angew. Chem. Int. Ed. Engl. 50(8) , 1896-900, (2011)

Pyridine elaboration through organometallic intermediates: regiochemical control and completeness.

Chem. Soc. Rev. 36(7) , 1161-72, (2007)

Pyridines carrying heterosubstituents (such as carboxy, amido, amino, alkoxy or trifluoromethyl groups or solely individual halogen atoms) can be readily and site selectively metalated. Subsequent rea...

Enhancement of CO₂/N₂ selectivity in a metal-organic framework by cavity modification. Bae YS, et al.

J. Mater. Chem. 19(15) , 2131-2134, (2009)