nci 143-474

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Names

[ CAS No. ]:
38128-83-5

[ Name ]:
nci 143-474

[Synonym ]:
rifamycin-AF/MO
rifaldehyde O-butyl-oxime
3-Formylrifamycin SV O-methyloxim
rifaldehyde O-methyl-oxime
3-Formylrifamycin SV O-n-Butyloxim
AF/MO

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Molecular Formula ]:
C42H56N2O13

[ Molecular Weight ]:
796.90000

[ Exact Mass ]:
796.37800

[ PSA ]:
222.90000

[ LogP ]:
6.04270

[ Index of Refraction ]:
1.603

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KD1768000
CHEMICAL NAME :
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 3-formyl-5,6,9 17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-he ptamethyl-, 21-acetate, O-butyloxime
CAS REGISTRY NUMBER :
38128-83-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C42-H56-N2-O13
MOLECULAR WEIGHT :
797.00
WISWESSER LINE NOTATION :
T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&U MH&&&TJ DQ E1UNO4 GQ IQ J1 M1 QO1 R1 SOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
73 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,396,1974

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(Aminooxy)butane
  • 3-Formyl Rifamycin

DownStream

Related Compounds

  • NCI 143-473
  • NCI 143-468
  • 9,4-(Epoxypentadeca(1,11,13)trienimino)-1H-benzofuro(5,4-g)indole-10,26(9H)-dione,3-acetyl-5,6,16,18,20-pentahydroxy-14-methoxy-1,2,7,9,15,17,19,21,25-nonamethyl-,16-acetate
  • NCI 143-447
  • NCI 143-475
  • 3-Formylrifamycin SV O-propyloxime
  • N-methyl-N-[(2-nitrophenyl)methyl]hydroxylamine
  • 2-(1-isocyanatocyclopropyl)-4,5,6,7-tetrahydro-1H-indole
  • tert-butyl N-[2-(1-formylcyclopropyl)-5-methoxyphenyl]carbamate
  • 2-[5-Chloro-2-(difluoromethoxy)phenyl]-1-methylpiperazine
  • 4-[1-(aminooxy)ethyl]-N,N-dimethylaniline
  • 3-(1,5-dimethyl-1H-pyrazol-4-yl)-2-methoxy-3-methylbutanoic acid
  • tert-butyl N-{4-[(2S)-2-aminopropyl]-3-hydroxyphenyl}carbamate
  • Tert-butyl 4-(2-amino-3,3-difluoro-2-methylpropyl)-3-methylpiperidine-1-carboxylate
  • Methyl 2-[1-(4-ethynylphenyl)cyclopropyl]-2-hydroxyacetate
  • 4-Amino-1-(1-methylpiperidin-4-yl)cyclohexane-1-carboxylic acid
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