nci 143-474

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Names

[ CAS No. ]:
38128-83-5

[ Name ]:
nci 143-474

[Synonym ]:
rifamycin-AF/MO
rifaldehyde O-butyl-oxime
3-Formylrifamycin SV O-methyloxim
rifaldehyde O-methyl-oxime
3-Formylrifamycin SV O-n-Butyloxim
AF/MO

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Molecular Formula ]:
C42H56N2O13

[ Molecular Weight ]:
796.90000

[ Exact Mass ]:
796.37800

[ PSA ]:
222.90000

[ LogP ]:
6.04270

[ Index of Refraction ]:
1.603

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KD1768000
CHEMICAL NAME :
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 3-formyl-5,6,9 17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-he ptamethyl-, 21-acetate, O-butyloxime
CAS REGISTRY NUMBER :
38128-83-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C42-H56-N2-O13
MOLECULAR WEIGHT :
797.00
WISWESSER LINE NOTATION :
T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&U MH&&&TJ DQ E1UNO4 GQ IQ J1 M1 QO1 R1 SOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
73 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,396,1974

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(Aminooxy)butane
  • 3-Formyl Rifamycin

DownStream

Related Compounds

  • NCI 143-473
  • NCI 143-468
  • 9,4-(Epoxypentadeca(1,11,13)trienimino)-1H-benzofuro(5,4-g)indole-10,26(9H)-dione,3-acetyl-5,6,16,18,20-pentahydroxy-14-methoxy-1,2,7,9,15,17,19,21,25-nonamethyl-,16-acetate
  • NCI 143-447
  • NCI 143-475
  • 3-Formylrifamycin SV O-propyloxime
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3,4-Dihydro-2-ethyl-4-(1-oxopropyl)-2H-pyrido(3,2-b)-1,4-oxazine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide