NCI 143-468

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Names

[ CAS No. ]:
38128-86-8

[ Name ]:
NCI 143-468

[Synonym ]:
3-Formylrifamycin-SV-O-phenylaethylenoxim
3-Formylrifamycin-SV-O-p-Brombenzyloxim
rifaldehyde O-phenethyl-oxime

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Molecular Formula ]:
C46H56N2O13

[ Molecular Weight ]:
844.94200

[ Exact Mass ]:
844.37800

[ PSA ]:
222.90000

[ LogP ]:
6.48530

[ Index of Refraction ]:
1.626

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KD1881000
CHEMICAL NAME :
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 3-formyl-5,6,9, 17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-he ptamethyl-, 21-acetate, O-phenethyloxime
CAS REGISTRY NUMBER :
38128-86-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C46-H56-N2-O13
MOLECULAR WEIGHT :
845.04
WISWESSER LINE NOTATION :
T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&U MH&&&TJ DQ E1UNO2R& GQ IQ J1 M1 QO1 R1 SOV

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
77 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,396,1974

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • O-(2-phenylethyl)hydroxylamine
  • 3-Formyl Rifamycin

DownStream

Related Compounds

  • nci 143-474
  • NCI 143-473
  • NCI 143-447
  • 9,4-(Epoxypentadeca(1,11,13)trienimino)-1H-benzofuro(5,4-g)indole-10,26(9H)-dione,3-acetyl-5,6,16,18,20-pentahydroxy-14-methoxy-1,2,7,9,15,17,19,21,25-nonamethyl-,16-acetate
  • NCI 143-475
  • 3-Formylrifamycin SV O-propyloxime