α-Fluoro-β-alanine

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Names

[ CAS No. ]:
3821-81-6

[ Name ]:
α-Fluoro-β-alanine

[Synonym ]:
3-amino-2-fluoropropanoic acid

Chemical & Physical Properties

[ Density]:
1.302g/cm3

[ Boiling Point ]:
264.5ºC at 760 mmHg

[ Melting Point ]:
222ºC

[ Molecular Formula ]:
C3H6FNO2

[ Molecular Weight ]:
107.08400

[ Flash Point ]:
113.8ºC

[ Exact Mass ]:
107.03800

[ PSA ]:
63.32000

[ LogP ]:
0.06810

[ Index of Refraction ]:
1.428

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922499990

Synthetic Route

Precursor & DownStream

Precursor

  • 3-Dibenzylamino-2-fluoropropionic acid, benzyl ester
  • fluoro-phthalimidomethyl-malonic acid diethyl ester

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

beta-alanine and alpha-fluoro-beta-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2.

Am. J. Physiol. 276(1 Pt 1) , G206-10, (1999)

Studies on the compartmentalization of uridine catabolic metabolism in liver have indicated accumulation of beta-alanine as well as alpha-fluoro-beta-alanine (FbetaAL) for 5-fluorouracil in the hepato...

Proton-decoupled 19F spectroscopy of 5-FU catabolites in human liver.

Magn. Reson. Med. 37(3) , 321-6, (1997)

An RF network and a dual-tuned surface coil are described for obtaining proton-decoupled, NOE enhanced 19F spectra from a whole body clinical imager operating at 1.5 Tesia. The network removes 19F fre...

The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(13-14) , 915-20, (2011)

5-Fluoro-2'-deoxyuridine (floxuridine, 5-FdUrd) and 5-fluorouracil (5-FU) are widely used for the treatment of colorectal cancers. The mechanisms of action of 5-FdUrd and 5-FU, as well as the biochemi...


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Related Compounds

  • 4-[3-[Cyano[[[3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropyl]carbonyl]oxy]methyl]phenoxy]phenyl beta-D-glucopyranosiduronic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • B-[4-[2-(4-aminophenyl)ethyl]phenyl]boronic acid
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine