Zinterol hydrochloride

Names

[ Name ]:
Zinterol hydrochloride

[Synonym ]:
N-[2-hydroxy-5-[1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl]phenyl]methanesulfonamide,hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
574.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₇ClN₂O₄S

[ Molecular Weight ]:
414.94700

[ Flash Point ]:
301.1ºC

[ Exact Mass ]:
414.13800

[ PSA ]:
107.04000

[ LogP ]:
4.75470

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB0512953

CHEMICAL NAME :: Methanesulfonanilide, 5'-(2-((alpha,alpha-dimethylphenethyl)amino)-1-hydrox yethyl)-2'- hydroxy-, monohydrochloride

CAS REGISTRY NUMBER :: 38241-28-0

LAST UPDATED :: 199007

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H26-N2-O4-S.Cl-H

MOLECULAR WEIGHT :: 414.99

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 19,626,1976

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor.

Mol. Pharmacol. 74(5) , 1417-28, (2008)

This study identifies signaling pathways activated by the beta(2)-/beta(3)-adrenoceptor (AR) agonist zinterol, the selective beta(3)-AR agonist L755507, and the selective beta(3)-AR antagonist L748337...

Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells.

Br. J. Pharmacol. 147(4) , 446-54, (2006)

1. Beta-adrenoceptor (AR) agonists increase 2-deoxy-[3H]-D-glucose uptake (GU) via beta2-AR in rat L6 cells. The beta-AR agonists, zinterol (beta2-AR) and (-)-isoprenaline, increased cAMP accumulation...

Rapid turnover of glycogen in memory formation.

Neurochem. Res. 37(11) , 2456-63, (2012)

The influence of noradrenaline acting at α(2)-AR and β(2)-ARs on the turnover of glycogen after learning has been investigated. The role of glycogen turnover in memory formation was examined using wea...