TRIETHYLENETETRAMINE DIHYDROCHLORIDE
Suppliers
Names
[ CAS No. ]:
38260-01-4
[ Name ]:
TRIETHYLENETETRAMINE DIHYDROCHLORIDE
[Synonym ]:
EINECS 253-854-3
MK-0681
Triethylenetetramine dihydrochloride
N,N'-bis(2-aminoéthyl)éthane-1,2-diamine dichlorhydrate
Trien dihydrochloride
Syprine
N,N'-Bis(2-aminoethyl)-1,2-ethanediamine dihydrochloride
Trientine hydrochloride
MFCD00012889
n,n'-bis(2-aminoethyl)ethan-1,2-diamindihydrochlorid
1,2-Ethanediamine, N,N-bis(2-aminoethyl)-, hydrochloride (1:2)
N,N'-Bis(2-aminoethyl)ethane-1,2-diamine dihydrochloride
trientine dihydrochloride
Triethylenetetraamine dihydrochloride
Chemical & Physical Properties
[ Density]:
0.958 g/cm3
[ Boiling Point ]:
266.5ºC at 760 mmHg
[ Melting Point ]:
120-125ºC (dec.)
[ Molecular Formula ]:
C6H20Cl2N4
[ Molecular Weight ]:
219.156
[ Flash Point ]:
143.3ºC
[ Exact Mass ]:
218.106506
[ PSA ]:
76.10000
[ LogP ]:
1.86940
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KH8587085
- CHEMICAL NAME :
- 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-, dihydrochloride
- CAS REGISTRY NUMBER :
- 38260-01-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C6-H18-N4.2Cl-H
- MOLECULAR WEIGHT :
- 219.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2285 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: (Suppl),246,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 67500 mg/kg/90D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Liver - fatty liver degeneration Blood - changes in spleen
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 29,185,1996 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1140 uL/kg
- SEX/DURATION :
- female 1-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo
- REFERENCE :
- JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 38,545,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 22800 mg/kg
- SEX/DURATION :
- female 1-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
- REFERENCE :
- JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 39,177,1993
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
KH8587085
[ HS Code ]:
2921290000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921290000
[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
Biochem. Pharmacol. 97 , 62-76, (2015)
Diabetes impairs copper (Cu) regulation, causing elevated serum Cu and urinary Cu excretion in patients with established cardiovascular disease; it also causes cardiomyopathy and chronic cardiac impai...