Acetamide, 2-chloro-N-[5,6,7,9-tetrahydro-1,2, 3-trimethoxy-10-(methylthio)-9-oxobenz[a]heptalen-7-yl]-, (S)-

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Names

[ CAS No. ]:
38479-08-2

[ Name ]:
Acetamide, 2-chloro-N-[5,6,7,9-tetrahydro-1,2, 3-trimethoxy-10-(methylthio)-9-oxobenz[a]heptalen-7-yl]-, (S)-

[Synonym ]:
17-Chloro-10-demethoxy-10-methylthiocolchicine

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Boiling Point ]:
749.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₄ClNO₅S

[ Molecular Weight ]:
449.94800

[ Flash Point ]:
406.9ºC

[ Exact Mass ]:
449.10600

[ PSA ]:
99.16000

[ LogP ]:
4.19470

[ Index of Refraction ]:
1.615

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB5839000

CHEMICAL NAME :: Acetamide, 2-chloro-N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(m ethylthio)-9-oxobenzo (a) heptalen-7-yl)-, (S)-

CAS REGISTRY NUMBER :: 38479-08-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H24-Cl-N-O5-S

MOLECULAR WEIGHT :: 449.98

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1G NS1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1007 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

Related Compounds

t-Butyl 2-[(5-chloro-3-methyl-1-benzothiophen-2-yl)carbonyl]hydrazinecarboxylate
t-Butyl 2-{[2-chloro-4-(pyrrolidin-1-yl)phenyl]carbonyl}hydrazinecarboxylate
4-Tert-butyl-3-(3-(pyrrolidin-1-yl)propyl)benzenamine
5-[(3-Methyl-4-propan-2-ylphenoxy)methyl]-4,5-dihydro-1,3-oxazol-2-amine
t-Butyl 2-{[2-chloro-4-(piperidin-1-yl)phenyl]carbonyl}hydrazinecarboxylate
6-Cyclohex-1-enyl-pyridin-3-ol
5-(1H-indol-5-yloxymethyl)-4,5-dihydro-1,3-oxazol-2-amine
3-(3,3-Diethoxypropoxy)phenylboronic acid
4',4'-Dimethyl-3',4'-dihydro-2'H-spiro[cyclopropane-1,1'-naphthalene]-2-amine
(Z)-2-(3-chloroprop-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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