2,6-Difluorobenzoic acid

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Names

[ CAS No. ]:
385-00-2

[ Name ]:
2,6-Difluorobenzoic acid

[Synonym ]:
QVR BF FF
2,6-difluoro-benzoic acid
Benzoic acid,2,6-difluoro
EINECS 206-856-3
2,6-difluorophenylcarboxylic acid
2,6-Difluor-benzoesaeure
2,6-Difluorobenzoicacid
2,6-Difluorobenzoic acid
MFCD00002411
Benzoic acid, 2,6-difluoro-
2,6-Difluoro benzoic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
231.0±20.0 °C at 760 mmHg

[ Melting Point ]:
157-161 °C(lit.)

[ Molecular Formula ]:
C7H4F2O2

[ Molecular Weight ]:
158.102

[ Flash Point ]:
93.5±21.8 °C

[ Exact Mass ]:
158.017929

[ PSA ]:
37.30000

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.513

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG8559000
CHEMICAL NAME :
Benzoic acid, 2,6-difluoro-
CAS REGISTRY NUMBER :
385-00-2
BEILSTEIN REFERENCE NO. :
0973774
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H4-F2-O2
MOLECULAR WEIGHT :
158.11
WISWESSER LINE NOTATION :
QVR BF FF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 mg/plate
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 10,174,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG8559000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Carbon dioxide
  • 1,3-Difluorobenzene
  • 2,6-Difluoroiodobenzene
  • 2,6-Difluorobenzonitrile
  • 3-bromo-2,6-difluorobenzoic acid
  • 2,6-Difluorobenzyl bromide
  • 2-Bromo-1,3-difluorobenzene
  • 1-Bromo-2,4-difluorobenzene
  • 2,6-Difluorobenzaldehyde

DownStream

  • 2,6-Difluorobenzoyl isocyanate
  • 1,3-Difluorobenzene
  • 2,6-Difluoroaniline
  • 3-chlorosulfonyl-2,6-difluorobenzoic acid
  • Diazene, bis(2,6-difluorophenyl)-1-oxide
  • Ethyl 2,6-difluorobenzoate
  • 2,6-Difluorobenzonitrile
  • Methyl 3-amino-2,6-difluorobenzoate
  • METHYL 2,6-DIFLUORO-3-NITROBENZOATE
  • 2,6-Difluoro-3-nitrobenzoic acid

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis of 2,6-difluoro-N-(3-[11C]methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide as a new potential PET agent for imaging of B-Raf(V600E) in cancers.

Bioorg. Med. Chem. Lett. 23(4) , 1017-21, (2013)

The authentic standard 2,6-difluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridine-5-yl)-3-(propylsulfonamidio)benzamide was synthesized from 2,6-difluorobenzoic acid and 3-amino-5-hydroxypyrazole in 9 steps...

Effect of diflubenzuron and its major degradation products on the growth of Euglena gracilis Z. and incorporation of glycine-U-14C in protein.

J. Environ. Sci. Health B 16(2) , 159-66, (1981)

Diflubenzuron (I) and its major degradation products 4-chlorophenyl urea (II), 2,6-difluorobenzoic acid (III) and 4-chloroaniline (IV) were tested for their activity on Euglena gracilis Z. The inhibit...

Synthesis and insecticidal evaluation of propesticides of benzoylphenylureas.

J. Agric. Food Chem. 53(1) , 38-41, (2005)

Two series of benzoylphenylurea derivatives were synthesized as candidate propesticides by a nucleophilic addition reaction between 2,6-difluronbenzoyl isocyanate and N-substitutedaniline. The new com...


More Articles

Related Compounds

  • 2,6-Difluorobenzoic acid-d3
  • 2,6-difluorobenzoic acid amide
  • 3-Iodo-2,6-difluorobenzoic acid
  • 3-Cyano-2,6-difluorobenzoic acid
  • 4-Bromo-2,6-difluorobenzoic acid
  • 3-Amino-2,6-difluorobenzoic acid
  • 4-(3,3-Dimethylbutoxy)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • N-[(1,5-Dimethyl-1H-pyrazol-4-yl)methyl]pyridin-3-amine
  • 3-(4-Chlorophenyl)-7-methoxypyrimido[5,4-b]indole-2,4-dione
  • 5-oxo-1-(tetrahydro-2H-pyran-4-yl)-N-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)pyrrolidine-3-carboxamide
  • N-(2-((3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetamide
  • 4-Amino-5-bromo-alpha-cyclopropylpyrrolo[2,1-f][1,2,4]triazine-7-methanol
  • 2-(4-chlorophenoxy)-N-((5-(furan-2-yl)-1-methyl-1H-pyrazol-3-yl)methyl)-2-methylpropanamide
  • 6-(Benzyloxy)-4-fluoropyridine-2-sulfonyl chloride
  • (4-(Ethyl(methyl)carbamoyl)-2-fluorophenyl)boronic acid
  • 4-Chloro-6-iodopyridine-2-sulfonyl chloride
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