Chloroprocaine Hydrochloride
Suppliers
Names
[ CAS No. ]:
3858-89-7
[ Name ]:
Chloroprocaine Hydrochloride
[Synonym ]:
NESACAINE-MPF
4-amino-2-chlorobenzoate de 2-(diéthylamino)éthyle chlorhydrate
2-diethylaminoethyl 4-amino-2-chlorobenzoate hydrochloride
Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate hydrochloride (1:1)
2-(Diethylamino)ethyl-4-amino-2-chlorbenzolcarboxylathydrochlorid
2-Chloro-4-aminobenzoic Acid Diethylaminoethyl Ester Hydrochloride
4-Amino-2-chlorobenzoic Acid 2-(Diethylamino)ethyl Ester Monohydrochloride
CHLOROPROCAINE HCL
Chloroprocaine Hydrochloride
2-(diethylamino)ethyl 4-amino-2-chlorobenzoate,hydrochloride
UNII-LT7Z1YW11H
Nesacaine
Chlorprocainchlorid
Chemical & Physical Properties
[ Boiling Point ]:
402.6ºC at 760 mmHg
[ Melting Point ]:
176ºC
[ Molecular Formula ]:
C13H20Cl2N2O2
[ Molecular Weight ]:
307.216
[ Exact Mass ]:
306.090179
[ PSA ]:
41.57000
[ LogP ]:
3.62590
[ Storage condition ]:
-20℃
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DG1575200
- CHEMICAL NAME :
- Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride
- CAS REGISTRY NUMBER :
- 3858-89-7
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C13-H19-Cl-N2-O2.Cl-H
- MOLECULAR WEIGHT :
- 307.25
- WISWESSER LINE NOTATION :
- ZR CG DVO2N2&2 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraspinal
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 9677 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - coma Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 66,677,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 266 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - local anesthetic Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,501,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 75,215,1955
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5336 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)
Safety Information
[ RIDADR ]:
NONH for all modes of transport