(R)?-?PIA

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Names

[ CAS No. ]:
38594-96-6

[ Name ]:
(R)?-?PIA

[Synonym ]:
(R)-N6-(1-Methyl-2-phenylethyl)adenosine N6-(L-2-Phenylisopropyl)adenosine R-(−)-PIA
EINECS 254-028-5
(−)-N6-(2-Phenylisopropyl)adenosine
MFCD00069194
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(2R)-1-phenylpropan-2-yl]amino]purin-9-yl]oxolane-3,4-diol

Chemical & Physical Properties

[ Density]:
1.506g/cm3

[ Boiling Point ]:
675.716ºC at 760 mmHg

[ Molecular Formula ]:
C19H23N5O4

[ Molecular Weight ]:
385.42

[ Flash Point ]:
362.46ºC

[ Exact Mass ]:
385.17500

[ PSA ]:
125.55000

[ LogP ]:
0.55390

[ Index of Refraction ]:
1.712

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU7404930
CHEMICAL NAME :
Adenosine, N-(1-methyl-2-phenylethyl)-, (R)-
CAS REGISTRY NUMBER :
38594-96-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H23-N5-O4
MOLECULAR WEIGHT :
385.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
770 ug/kg
SEX/DURATION :
female 11-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25(2),35A,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

Mol. Pharmacol. 29 , 331, (1986)

[3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuronamide) is known to bind to both the A1 and A2 subtypes of adenosine receptor in rat striatal membranes. In order to study the putati...

Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate.

Neurosci. Lett. 459 , 127-131, (2009)

At the rat motor nerve terminals, activation of muscarinic M(1) receptors negatively modulates the activity of inhibitory muscarinic M(2) receptors. The present work was designed to investigate if the...

Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors.

J. Pharmacol. Exp. Ther. 322(1) , 332-40, (2007)

The inactivation of synaptic serotonin (5-hydroxytryptamine, 5-HT) is largely established through the actions of the presynaptic, antidepressant-sensitive 5-HT transporter (SERT, SLC6A4). Recent studi...


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