cis-BIS(CYCLOPENTYLAMMINE)PLATINUM(II)
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Names
[ CAS No. ]:
38780-36-8
[ Name ]:
cis-BIS(CYCLOPENTYLAMMINE)PLATINUM(II)
[Synonym ]:
UC 51
EINECS 254-125-2
Pt-11
Chemical & Physical Properties
[ Boiling Point ]:
110ºC at 760 mmHg
[ Molecular Formula ]:
C10H22Cl2N2Pt
[ Molecular Weight ]:
436.27900
[ Flash Point ]:
17.2ºC
[ Exact Mass ]:
435.08100
[ PSA ]:
52.04000
[ LogP ]:
4.55250
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TP2210000
- CHEMICAL NAME :
- Platinum (II), bis(cyclopentylammine)dichloro-, cis-
- CAS REGISTRY NUMBER :
- 38780-36-8
- LAST UPDATED :
- 199410
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C10-H22-Cl2-N2-Pt
- MOLECULAR WEIGHT :
- 436.33
- WISWESSER LINE NOTATION :
- L5TJ AZ 2 &G-PT-G -C
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 480 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Tumorigenic - facilitates action of known carcinogen
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 480 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 109 mg/kg/6W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 189 mg/kg/10W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 46 mg/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 14,217,1976