Lapatinib ditosylate hydrate

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Names

[ CAS No. ]:
388082-78-8

[ Name ]:
Lapatinib ditosylate hydrate

[Synonym ]:
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]quinazolin-4-amine bis(4-methylbenzenesulfonate) hydrate
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine 4-methylbenzenesulfonate hydrate (1:2:1)
Lapatinib ditosylate (USAN)
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, 4-methylbenzenesulfonate, hydrate (1:2:1)
T66 BN DNJ EMR CG DO1R CF&& H- BT5OJ E1M2SW1 &&2 p-Tosoh H2O
Lapatinib Ditosilate
4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate, hydrate (1:2:1)
Lapatinib ditosylate monohydrate
Lapatinib Ditosylate

Chemical & Physical Properties

[ Density]:
1.403 g/mL (20.84 °C)

[ Boiling Point ]:
750.7ºC at 760 mmHg

[ Melting Point ]:
237 - 239 °C

[ Molecular Formula ]:
C86H86Cl2F2N8O21S6

[ Molecular Weight ]:
943.476

[ Flash Point ]:
68 °F

[ Exact Mass ]:
942.184143

[ PSA ]:
249.46000

[ LogP ]:
12.26450

[ Index of Refraction ]:
n20/D 1.5520(lit.)

Safety Information

[ Hazard Codes ]:
Xi,N

[ Risk Phrases ]:
R43:May cause sensitization by skin contact. R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .

[ Safety Phrases ]:
S24-S37-S61

Precursor & DownStream

Precursor

  • p-Toluenesulfonic acid
  • 2-Aminoethylmethylsulfone hydrochloride
  • 5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde
  • 2-Aminoethyl methyl sulfone
  • N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine
  • Lapatinib (GW572016)
  • N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine
  • aminobenzonitrile
  • 2-Amino-5-iodobenzonitrile

DownStream

  • Lapatinib (GW572016)

Related Compounds

  • Lapatinib ditosylate hydrate
  • Lapatinib (GW-572016) Ditosylate
  • Lapatinib-d7 ditosylate
  • Lapatinib-13C2,15N Ditosylate
  • Lapatinib impurity H
  • Lapatinib-13C2,15N
  • Methyl 1-methyl-1H-thieno[2,3-d]-1,2,3-triazole-5-carboxylate
  • Methyl 3-formylpyrrolidine-3-carboxylate
  • 1-Cyclopropyl-2-(ethylamino)propan-1-one
  • 3-Amino-3-(thietan-3-yl)butanoic acid
  • 4-[N-(pyridin-3-yl)acetamido]benzoic acid
  • 2-amino-N,N,3-trimethylpentane-1-sulfonamide
  • 4-[(3S)-3-aminobutyl]-2-bromo-6-ethoxyphenol
  • Methyl 4-amino-4-(2-methyl-1,3-thiazol-5-yl)butanoate
  • tert-butyl N-[2-(3,5-dimethoxyphenyl)-1-oxopropan-2-yl]carbamate
  • Ethyl 2-(1-amino-2,2-dimethylcyclobutyl)acetate
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