SIA Crosslinker

Suppliers

Names

[ CAS No. ]:
39028-27-8

[ Name ]:
SIA Crosslinker

[Synonym ]:
1-(2-Iodoacetoxy)-2,5-pyrrolidinedione
N-SucciniMidyl Iodoacetate
2,5-Pyrrolidinedione, 1-[(2-iodoacetyl)oxy]-
N-(Iodoacetoxy)succinimide
1-(2-Iodoacetoxy)pyrrolidine-2,5-dione
Iodoacetic Acid N-Succinimidyl Ester
(2,5-dioxopyrrolidin-1-yl) 2-iodoacetate
N-Succinimidyl iodoacetate(SIA)

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
315.6±44.0 °C at 760 mmHg

[ Melting Point ]:
148ºC

[ Molecular Formula ]:
C6H6INO4

[ Molecular Weight ]:
283.021

[ Flash Point ]:
144.7±28.4 °C

[ Exact Mass ]:
282.934143

[ PSA ]:
63.68000

[ LogP ]:
-0.76

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMF: 50 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-Hydroxysuccinimide
  • Iodoacetic acid

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

A method for the preparation of protein-protein conjugates of predetermined composition.

J. Immunol. Methods 24 , 321-336, (1978)

A novel procedure for the synthesis of well-defined protein-protein conjugates is described using ovalbumin (OA) and IgG as test proteins. This procedure involves the highly selective and rapid reacti...

Conjugation to preactivated proteins using divinylsulfone and iodoacetic acid.

J. Immunol. Methods 181 , 187-200, (1995)

Two methods for the preactivation of proteins and conjugation of peptides to proteins under mild conditions are presented. Preactivation of proteins with divinylsulfone (DVS) permits peptide conjugati...

Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.

ACS Nano 7 , 9001-9, (2013)

Thrombin is a serine protease and regulator of hemostasis that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with nu...


More Articles

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