PD0325901

Suppliers

Names

[ Name ]:
PD0325901

[Synonym ]:
N-[(2R)-2,3-dihydroxyproposy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Benzamide, N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-
(R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide
PD 0325901
N-[(R)-2,3 -Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide
PD0325901

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Melting Point ]:
112-114ºC

[ Molecular Formula ]:
C₁₆H₁₄F₃IN₂O₄

[ Molecular Weight ]:
482.193

[ Exact Mass ]:
481.995026

[ PSA ]:
90.82000

[ LogP ]:
6.16

[ Appearance of Characters ]:
white to off-white

[ Index of Refraction ]:
1.645

[ Storage condition ]:
Store at -20°C

[ Water Solubility ]:
DMSO: soluble20mg/mL, clear

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H373-H410

[ Precautionary Statements ]:
P273-P301 + P310 + P330-P391-P501

[ Hazard Codes ]:
T,N

[ Risk Phrases ]:
25-48-50

[ Safety Phrases ]:
22-36/37/39-61

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid
(S)-N-CARBOBENZYLOXYCYCLOHEXYLALANINOL
N-{[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide

DownStream

Articles

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway.

PLoS Pathog. 11 , e1005091, (2015)

Chikungunya virus (CHIKV), the causative agent of a major epidemic spanning five continents, is a positive stranded mRNA virus that replicates using the cell's cap-dependent translation machinery. Des...

cAMP and EPAC Signaling Functionally Replace OCT4 During Induced Pluripotent Stem Cell Reprogramming.

Mol. Ther. 23 , 952-63, (2015)

The advent of induced pluripotent stem cells--generated via the ectopic overexpression of reprogramming factors such as OCT4, SOX2, KLF4, and C-MYC (OSKM) in a differentiated cell type--has enabled gr...

Mesenchymal stem cell-derived inflammatory fibroblasts promote monocyte transition into myeloid fibroblasts via an IL-6-dependent mechanism in the aging mouse heart.

FASEB J. 29 , 3160-70, (2015)

Fibrosis in the old mouse heart arises partly as a result of aberrant mesenchymal fibroblast activation. We have previously shown that endogenous mesenchymal stem cells (MSCs) in the aged heart are ma...

3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{[(2-methyloxan-4-yl)methyl]carbamoyl}propanoic acid
2-{1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1,2,5-oxadiazol-3-yl]-N-(2-hydroxyethyl)formamido}acetic acid
(2S)-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylpropanamido]hexanoic acid
2-{4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-1H-pyrazol-1-yl}acetic acid
6-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanamido]-4-methylhexanoic acid
2-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(2-hydroxyethyl)-3-methylpentanamido]acetic acid
2-{1-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]pyrrolidin-2-yl}acetic acid
(2S)-3-cyclopropyl-2-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanamido]propanoic acid
2-ethyl-3-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]-1,3-thiazolidine-4-carboxylic acid
1-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]-4-hydroxypiperidine-4-carboxylic acid

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