3,4-Dihydroxy-5-methoxybenzaldehyde

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Names

[ CAS No. ]:
3934-87-0

[ Name ]:
3,4-Dihydroxy-5-methoxybenzaldehyde

[Synonym ]:
3-hydroxyvanillin
3,4-Dihydroxy-5-methoxybenzaldehyde
Benzaldehyde, 3,4-dihydroxy-5-methoxy-
Protocatechualdehyde,5-methoxy
3,4-dihydroxy-5-methoxy-benzaldehyd
5-METHOXY-3,4-DIHYDROXYBENZALDEHYDE
3,4-dihydroxy-5-methoxy-benzaldehyde
5-Methoxyprotocatechualdehyde
MFCD00016610
3,4-Dihydroxy-5-methoxybenzolcarbaldehyd
5-methoxy-protocatechualdehyd
3,4-dihydroxy-5-methoxybenzadehyde
EINECS 223-513-3
3,4-Dihydroxy-5-methoxybenzaldehdye
4,5-dihydroxy-3-methoxybenzaldehyde
3-METHOXY-4,5-DIHYDROXYBENZALDEHYDE

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
339.9±37.0 °C at 760 mmHg

[ Melting Point ]:
131-134°C

[ Molecular Formula ]:
C8H8O4

[ Molecular Weight ]:
168.147

[ Flash Point ]:
143.1±20.0 °C

[ Exact Mass ]:
168.042252

[ PSA ]:
66.76000

[ LogP ]:
1.05

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.631

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU5620000
CHEMICAL NAME :
Benzaldehyde, 3,4-dihydroxy-5-methoxy-
CAS REGISTRY NUMBER :
3934-87-0
BEILSTEIN REFERENCE NO. :
1956546
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H8-O4
MOLECULAR WEIGHT :
168.16
WISWESSER LINE NOTATION :
VHR CQ DQ EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,178,1964

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
CU5620000

[ HS Code ]:
2912499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Bromovanillin
  • 5-Iodovanillin
  • Syringaldehyde
  • 2-bromo-3,4-dihydroxy-5-methoxybenzaldehyde
  • Vanillin
  • Benzaldehyde,3-bromo-4,5-dihydroxy-
  • Sodium Methylate
  • 3,4-Dihydroxybenzaldehyde
  • 1,3-Benzenedicarboxaldehyde,4-hydroxy-5-methoxy-
  • 3,4-Dihydroxy-5-methoxybenzoic acid

DownStream

  • (E)-5-Hydroxyferulic acid
  • 3,4-Dimethoxy-5-hydroxybenzaldehyde
  • 3,4,5-Trimethoxybenzaldehyde
  • Syringaldehyde
  • myristicin aldehyde
  • 3-methoxy-4,5-bis(phenylmethoxy)benzaldehyde
  • 5-Hydroxyferulic acid
  • 5-(bromomethyl)-1-methoxy-2,3-bis(phenylmethoxy)benzene
  • 2-bromo-3,4-dihydroxy-5-methoxybenzaldehyde
  • 8-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBALDEHYDE

Customs

[ HS Code ]: 2912499000

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

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MESCALINE ANALOGS. III. 2, 4, 6-TRIALKYL-AND 3, 4-DIHYDROXY-5-METHOXY-ß-PHENETHYLAMINES. Benington F, et al.

J. Org. Chem. 20(9) , 1292-1296, (1955)

Structure and synthesis of (±)-Wuweizisu C. Schneiders GE and Stevenson R.

J. Org. Chem. 46(41) , 2969-71, (1981)


More Articles

Related Compounds

  • 3,4-DIHYDROXY-5-METHOXYBENZALDEHYDE OXIME
  • 2-bromo-3,4-dihydroxy-5-methoxybenzaldehyde
  • 2,6-dichloro-3,4-dihydroxy-5-methoxybenzaldehyde
  • 3,4-Dihydroxy-5-Nitrobenzoic Acid
  • 3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-carbaldehyde
  • 3,4-dihydroxy-5-methyl-1H-pyridin-2-one
  • 3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbut-2-enamido]bicyclo[3.1.0]hexane-1-carboxylic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • Ethyl 6-(2-methylpiperidin-4-yl)piperidine-3-carboxylate
  • 2-(3,3-Dimethylbutyl)cyclobutan-1-ol
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-[(3S)-3-aminobutyl]-4-bromo-6-methoxyphenol
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide