4-(4-Chlorophenyl)-4-piperidinol

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Names

[ CAS No. ]:
39512-49-7

[ Name ]:
4-(4-Chlorophenyl)-4-piperidinol

[Synonym ]:
4-Piperidinol, 4-(4-chlorophenyl)-
4-(p-Chlorophenyl)-4-piperidinol
Haloperidol metabolite I
4-(4-Chlorophenyl)-4-piperidinol
4-(4-Chlorophenyl)piperidin-4-ol
4-Hydroxy-4-(p-chlorophenyl)piperidine
EINECS 254-479-8
4-(para-Chlorophenyl)-4-hydroxypiperidine
4-(p-Chlorophenyl)-4-hydroxypiperidine
MFCD00006001
4-(4-Chlorophenyl)-4-hydroxypiperidine,crystalline
4-p-Chlorophenyl-4-piperidinol
4-p-chlorophenyl-4-hydroxypiperidine
4-(4-Chlorophenyl)-4-hydroxypiperidine
4-Piperidinol, 4- (4-chlorophenyl)-
4-Hydroxy-4-(4-chlorophenyl)piperidine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
344.5±42.0 °C at 760 mmHg

[ Melting Point ]:
137-140 °C(lit.)

[ Molecular Formula ]:
C11H14ClNO

[ Molecular Weight ]:
211.688

[ Flash Point ]:
162.1±27.9 °C

[ Exact Mass ]:
211.076385

[ PSA ]:
32.26000

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.572

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
340 mg/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE
  • 4-(4-Chlorophenyl)-4-Bromopiperide

DownStream

  • 1-Benzyl-4-(p-chlorophenyl)-4-piperidinol
  • BX 513 hydrochloride
  • Loperamide hydrochloride
  • 4-(4-Chlorophenyl)1,2,3,6-
  • 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE
  • 4-(4-Chlorophenyl)-4-hydroxy-a,a-diphenyl-1-piperidinebutanenitrile
  • haloperidol
  • Loperamide
  • N-Didesmethyl Loperamide
  • L-741,626

Customs

[ HS Code ]: 29333999

Articles

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Psychopharmacology 205 , 21-33, (2009)

We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice.Subcutan...

In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.

Pharmacogenetics 8(5) , 383-9, (1998)

In-vitro studies were performed using human liver microsomes and c-DNA-expressed human P450 isoforms to identify the cytochrome P450 isoenzyme(s) involved in the back oxidation and N-dealkylation of r...

Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites.

J. Am. Soc. Mass Spectrom. 13(3) , 204-8, (2002)

Sonic spray ionization (SSI) was compared with atmospheric pressure chemical ionization (APCI) as an interface of high-performance liquid chromatography (HPLC)-mass spectrometry (MS) for sensitive ana...


More Articles

Related Compounds

  • 1-BENZYL-4-(4-CHLOROPHENYL)-4-PIPERIDINOL
  • 4-(4-Chlorophenyl)-4-piperidinol hydrochloride (1:1)
  • N-Benzyloxycarbonyl-4-(4-chlorophenyl)-4-piperidinol
  • [4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methylidenecyanamide
  • 4-(4-chlorophenyl)-4-phenylbutan-2-one
  • 4-(4-Chlorophenyl)-4-Bromopiperide
  • 5-(Ethylphenylamino)pentanenitrile
  • 2-(Methyl((3-(p-tolyl)-1,2,4-oxadiazol-5-yl)methyl)amino)ethan-1-ol
  • N-(3,3,3-trifluoropropyl)cyclohexanamine
  • 2-((2-(4-Methoxyphenoxy)ethyl)(methyl)amino)ethan-1-ol
  • 3,3-dimethyl-N-phenethylbutan-1-amine
  • 2-methyl-3-(1H-1,2,3-triazol-1-yl)aniline
  • 3-fluoro-2-(1H-1,2,3-triazol-1-yl)benzoic acid
  • 1-(2-[1,3]Dioxan-2-yl-ethyl)-1h-indole-4-carboxylic acid
  • 2-[(2-Hydroxyethyl)methylamino]-N-(tetrahydro-1,1-dioxido-3-thienyl)acetamide
  • 2-((2-Hydroxyethyl)(methyl)amino)-1-(2-methylpiperidin-1-yl)ethan-1-one
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