2-Amino-4-chlorophenol

Names

[ Name ]:
2-Amino-4-chlorophenol

[Synonym ]:
2-Amino-4-chlorophenol
4-Amino-2-chlorophenol
Phenol, 2-amino-4-chloro-
MFCD00128891
3-Chloro-4-Hydroxyaniline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
276.8±25.0 °C at 760 mmHg

[ Melting Point ]:
150-153 °C(lit.)

[ Molecular Formula ]:
C₆H₆ClNO

[ Molecular Weight ]:
143.571

[ Flash Point ]:
121.2±23.2 °C

[ Exact Mass ]:
143.013794

[ PSA ]:
46.25000

[ LogP ]:
1.67

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.651

[ Storage condition ]:
2~8℃

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Chloro-4-nitrophenol
N-Methylpyrrolidone
2-Chlorophenol
2,2'-dichloro-4,4'-azo-di-phenol
Phenol,2-chloro-4-(2-phenyldiazenyl)-
2-chloro-4,4'-azo-di-phenol
Phenol,4,4'-(1,2-diazenediyl)bis-
3-Chlorophenylhydroxylamine
3-Nitrochlorobenzene
Sulfuric acid

DownStream

3-Chloro-4-[(pyridin-2-yl)methyloxy]aniline
4-Amino-2,6-dichlorophenol
Lapatinib ditosylate hydrate
N-(3-Chloro-4-hydroxyphenyl)acetamide
3-CHLORO-4-{[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY}ANILINE
2,5-Cyclohexadiene-1,4-dione,2-chloro-
Novaluron
1-(3-Chloro-4-hydroxyphenyl)-3,3-dimethylurea
N-(5-chloro-2-hydroxyphenyl)acetamide
2-Chloro-4-iodophenol

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Rapid determination of aniline metabolites of chlorpropham in potatoes by micellar electrokinetic chromatography using negative-charged mixed micelles and laser-induced fluorescence detection.

Electrophoresis 26(15) , 2991-8, (2005)

A rapid, reliable method has been developed for the multi-residue analysis of aniline metabolites of chlorpropham in potato samples. The method involves the precolumn derivatization of aniline metabol...

Nephrotoxicity of 4-amino-2-chlorophenol and 2-amino-4-chlorophenol in the Fischer 344 rat.

Toxicology 110(1-3) , 47-58, (1996)

Aminophenols and halogenated anilines induce nephrotoxicity and mild hepatotoxicity in rats. In this study, the in vivo and in vitro nephrotoxic potential of 4-amino-2-chlorophenol and 2-amino-4-chlor...

4-Amino-2-chlorophenol: Comparative in vitro nephrotoxicity and mechanisms of bioactivation.

Chem. Biol. Interact. 222C , 126-132, (2014)

Chlorinated anilines are nephrotoxicants both in vivo and in vitro. The mechanism of chloroaniline nephrotoxicity may occur via more than one mechanism, but aminochlorophenol metabolites appear to con...

2-Amino-4-chlorophenol
N-acetyl-2-amino-4-chlorophenol
2-Amino-4-chlorophenol hydrochloride
2-amino-4-chlorophenol-5-sulphonamide
2-Amino-4-chlorophenol-6-sulfonic acid
2-Amino-4-bromo-3-chlorophenol
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
N-((4-phenyl-5-((3-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)benzamide
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
1-(3-Bromo-2,4,6-trimethylbenzenesulfonyl)-4-(3-chloro-2-methylphenyl)piperazine