Acetamide,N-(4'-fluoro[1,1'-biphenyl]-4-yl)-

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Names

[ CAS No. ]:
398-32-3

[ Name ]:
Acetamide,N-(4'-fluoro[1,1'-biphenyl]-4-yl)-

[Synonym ]:
N-(4'-Fluor-biphenyl-4-yl)-acetamid
N-4-(4'-Fluoro)biphenylacetamide
N-(4'-fluoro-biphenyl-4-yl)-acetamide
4'-Fluor-4-biphenylacetanilid
MFCD00017955
4'-(p-Fluorophenyl)acetanilide
4'-Fluor-4-acetamino-diphenyl
4'-Fluoro-4-biphenylacetamide
N-(4'-Fluoro-4-biphenylyl)acetamide
4-Acetamido-4'-fluorbiphenyl
4'-Fluoro-4-acetylaminobiphenyl
ACETANILIDE,4'-(p-FLUOROPHENYL)
EINECS 206-912-7
N-[4'-fluoro(1,1'-biphenyl)-4-yl]acetamide
Acetamide,N-(4'-fluoro-4-biphenylyl)
4-Fluoro-4'-acetamidobiphenyl

Chemical & Physical Properties

[ Density]:
1.193g/cm3

[ Boiling Point ]:
416.1ºC at 760mmHg

[ Melting Point ]:
205-207ºC

[ Molecular Formula ]:
C₁₄H₁₂FNO

[ Molecular Weight ]:
229.25000

[ Flash Point ]:
205.5ºC

[ Exact Mass ]:
229.09000

[ PSA ]:
29.10000

[ LogP ]:
3.52410

[ Index of Refraction ]:
1.593

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE3750000

CHEMICAL NAME :: Acetanilide, 4'-(p-fluorophenyl)-

CAS REGISTRY NUMBER :: 398-32-3

BEILSTEIN REFERENCE NO. :: 2806508

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H12-F-N-O

MOLECULAR WEIGHT :: 229.27

WISWESSER LINE NOTATION :: FR DR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4032 mg/kg/24W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :: AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 100,317,1980

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8064 mg/kg/48W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :: JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1537,1980

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6048 mg/kg/36W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,217,1976

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg/36W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,427,1975

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6048 mg/kg/36W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 23,464,1979

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5040 mg/kg/36W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,1223,1975

Safety Information

[ Safety Phrases ]:
S24/25

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,1'-Biphenyl,4-fluoro-4'-nitro-
acetic acid
4'-(4-fluorophenyl)acetophenone oxime

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

N-hydroxy-4'-fluoro-4-(acetylamino)biphenyl sulfate
Acetamide,N-(4'-methyl[1,1'-biphenyl]-4-yl)-
Acetamide,N-(4'-amino[1,1'-biphenyl]-4-yl)-
4-nitro-4'-(acetylamino)biphenyl
N-(5,7-difluoro-3H-benzoimidazol-4-yl)acetamide
N-hydroxy-N'-acetylbenzidine
(2S,3S,3aR,4aS,5aR,5bR)-3-Fluoro-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)octahydrocyclopropa[4,5]cyclopenta[1,2-b]furan-3a,5a-diyl diacetate
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide