6-fluoroindole

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Names

[ CAS No. ]:
399-51-9

[ Name ]:
6-fluoroindole

[Synonym ]:
6-FLUOROINDOLE FOR SYNTHESIS 25 G
6-Fluoroindole
6-fluoro indole
6-FLUORO-2-IODOBENZALDEHYDE
6-Fluoro-1H-indole
1H-Indole, 5-fluoro-
5-Fluoro-1H-indole
MFCD00056933
5-Fluoro indole
6-FLUOROINDOLE FOR SYNTHESIS 5 G
1H-INDOLE,6-FLUORO
1H-Indole, 6-fluoro-
5-Fluoroindole

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
258.0±13.0 °C at 760 mmHg

[ Melting Point ]:
72-76 °C(lit.)

[ Molecular Formula ]:
C₈H₆FN

[ Molecular Weight ]:
135.14

[ Flash Point ]:
109.9±19.8 °C

[ Exact Mass ]:
135.048431

[ PSA ]:
15.79000

[ LogP ]:
2.19

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.646

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(4-fluoro-2-nitrophenyl)-N,N-dimethylethenamine
4-Fluoro-2-nitrotoluene
N,N-Dimethylformamide dimethyl acetal
1-Dimethylamino-2-(4-fluoro-2-nitro)phenylethene
6-Fluoroindole-2-carboxylic acid
Benzenamine, 2-ethynyl-5-fluoro- (9CI)
4-Fluorobenzaldehyde
6-Fluoro-1H-indole-2-carboxylic acid methyl ester
Ethyl 6-fluoroindole-2-carboxylate

DownStream

TERT-BUTYL 6-FLUOROINDOLINE-1-CARBOXYLATE
6-Fluoroindoline-2,3-dione
4-Fluoroisatoic anhydride
(6-Fluoro-1H-indol-3-yl)acetic acid
3-Bromo-7-fluoroquinoline
1-(6-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
6-Fluoroindoline
6-Fluoro-2-phenyl-1H-indole
LM10
6-Fluoro-1H-indole-3-carbonitrile

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

J. Med. Chem. 54 , 5320, (2011)

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active...

Ionization potentials of fluoroindoles and the origin of nonexponential tryptophan fluorescence decay in proteins.

J. Am. Chem. Soc. 127(11) , 4104-13, (2005)

This work reports an explanation for the unusual monoexponential fluorescence decay of 5-fluorotryptophan (5FTrp) in single-Trp mutant proteins [Broos, J.; Maddalena, F.; Hesp, B. H. J. Am. Chem. Soc....

Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.

J. Med. Chem. 54 , 166, (2011)

A novel series of N-linked β-D-xylosides were synthesized and evaluated for inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) in a cell-based assay. Of these, the 4-chloro-3...

3-iodo-6-fluoroindole
7-Bromo-6-fluoroindole
4-Amino-6-fluoroindole
4-Bromo-6-fluoroindole
5-bromo-6-fluoroindole
5-bromo-6-fluoroindole
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
N-benzyl-4-oxo-3-phenyl-3,4-dihydroquinazoline-7-carboxamide
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(6-oxo-3-pyridin-4-ylpyridazin-1(6{H})-yl)acetic acid
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine