5-Fluoroindole-2-carboxylic acid

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Names

[ CAS No. ]:
399-76-8

[ Name ]:
5-Fluoroindole-2-carboxylic acid

[Synonym ]:
5-Fluoro-1H-indole-2-carboxylic acid
5-Fluoroindole-2-carboxylic acid
1H-Indole-2-carboxylic acid, 5-fluoro-
MFCD00005612
EINECS 206-919-5

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
422.2±25.0 °C at 760 mmHg

[ Melting Point ]:
259 °C (dec.)(lit.)

[ Molecular Formula ]:
C9H6FNO2

[ Molecular Weight ]:
179.148

[ Flash Point ]:
209.1±23.2 °C

[ Exact Mass ]:
179.038254

[ PSA ]:
53.09000

[ LogP ]:
2.45

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.692

[ Storage condition ]:
0-6°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Precursor & DownStream

Precursor

  • Ethyl 5-fluoro-1H-indole-2-carboxylate
  • Hydrazine, (p-fluorophenyl)-, hydrochloride
  • 4-Fluoroaniline
  • Propanoic acid, 2-(4-fluorophenylhydrazono)-, ethyl ester
  • 4-fluorobenzenediazonium,chloride

DownStream

  • Ethyl 5-fluoro-1H-indole-2-carboxylate
  • (5-Fluoro-1H-indol-3-yl)acetic acid
  • 5-Fluoroindole
  • 1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine
  • CP-226269
  • Methyl 5-fluoro-1H-indole-2-carboxylate
  • 1H-INDOLE-2-CARBONYL CHLORIDE,5-FLUORO-
  • 1-(5-Fluoro-1H-indol-3-yl)ethanone
  • 5-fluoro-N-(3-hydroxyphenyl)-1H-indole-2-carboxamide

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

J. Enzyme Inhib. Med. Chem. 29(6) , 846-67, (2014)

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatme...

Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.

Chem. Biol. 13(3) , 261-8, (2006)

Severe acute respiratory syndrome (SARS) is caused by a newly emerged coronavirus that infected more than 8000 individuals and resulted in more than 800 fatalities in 2003. Currently, there is no effe...

Effect of 5-fluoroindole-2-carboxylic acid (an antagonist of the NMDA receptor-associated glycine site) on the anticonvulsive activity of conventional antiepileptic drugs.

J. Neural Transm. Gen. Sect. 105(2-3) , 133-46, (1998)

5-Fluoroindole-2-carboxylic acid, an antagonist of the glycine site within the NMDA receptor complex, administered intraperitoneally in doses of 150 and 200 mg/kg, 120 min before electroconvulsions, s...


More Articles


Related Compounds

  • 5-fluoroindole-2-carboxylic acid chloride
  • 5-Fluoroindole-2-carboxylic acid ethyl ester
  • 6-Fluoroindole-2-carboxylic acid
  • 1-Boc-5-fluoroindole-2-boronic acid
  • 5-Chloro-7-fluoro-1H-indole-2-carboxylicacid
  • 5-Chloro-4-fluoro-1h-indole-2-carboxylicacid
  • 3-(2-Aminocyclopropyl)-4-nitrophenol
  • 2-(3,5-Difluoro-2-hydroxyphenyl)cyclopropane-1-carboxylic acid
  • 2-{1-[5-(2-Aminoethyl)-1,2,4-oxadiazol-3-yl]piperidin-4-yl}acetic acid
  • 3-Amino-3-{spiro[2.2]pentan-1-yl}propanoic acid
  • (2R)-2-amino-5-cyano-5,5-dimethylpentanoic acid
  • 3-(3,5-Difluoropyridin-4-yl)-2-methoxypropanoic acid
  • methyl 1-methyl-4-(5-oxopyrrolidin-3-yl)-1H-pyrrole-2-carboxylate
  • 2-Amino-2-(1-cyclopentylcyclopropyl)acetic acid
  • 3-hydroxy-3-[1-(piperidin-3-yl)-1H-1,2,3-triazol-4-yl]cyclobutane-1-carboxylic acid
  • 1-(1-{4-[(Difluoromethyl)sulfanyl]phenyl}cyclopropyl)cyclopropan-1-amine