Nitroxoline
Suppliers
Names
[ CAS No. ]:
4008-48-4
[ Name ]:
Nitroxoline
[Synonym ]:
5-nitryl-8-hydroxyquinoline
EINECS 223-662-4
Nitroxolina
5-Nitro-8-quinolinol
Notroxoline
Enterocol
5-Nitro-8-hydroxyquinoline
MFCD00006791
Nitroxolinum
8-Quinolinol, 5-nitro-
5-Hydroxy-8-nitroquinoline
5-nitroquinolin-8-ol
Noxibiol
Nitroxolin
Urocoli
Nitroxoline
Uritrol
8-Hydroxy-5-Nitroquinoline
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
419.0±35.0 °C at 760 mmHg
[ Melting Point ]:
181-183ºC
[ Molecular Formula ]:
C9H6N2O3
[ Molecular Weight ]:
190.156
[ Flash Point ]:
207.2±25.9 °C
[ Exact Mass ]:
190.037842
[ PSA ]:
78.94000
[ LogP ]:
2.00
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.728
[ Water Solubility ]:
alcohol: very slightly soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VC8225000
- CHEMICAL NAME :
- 8-Quinolinol, 5-nitro-
- CAS REGISTRY NUMBER :
- 4008-48-4
- BEILSTEIN REFERENCE NO. :
- 0166146
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C9-H6-N2-O3
- MOLECULAR WEIGHT :
- 190.17
- WISWESSER LINE NOTATION :
- T66 BNJ GNW JQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 510 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 104 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8300 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13 gm/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 26 gm/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 52 gm/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311 + H331-H315-H319-H335
[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R22/24/25;R36/37/38
[ Safety Phrases ]:
S26-S36-S45
[ RIDADR ]:
UN 2811
[ WGK Germany ]:
3
[ RTECS ]:
VC8225000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2933499090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Med. Chem. 56(2) , 521-33, (2013)
Human cathepsin B has many house-keeping functions, such as protein turnover in lysosomes. However, dysregulation of its activity is associated with numerous diseases, including cancers. We present he...
PLoS ONE 6(11) , e27197, (2011)
Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughp...
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 506-16, (2012)
The FT-IR and FT-Raman spectra of 8-hydroxy-5-nitroquinoline have been recorded in the regions 4000-400 and 4000-100 cm(-1), respectively. The spectra were interpreted in terms of fundamentals modes, ...