Tienilic acid
Suppliers
Names
[ CAS No. ]:
40180-04-9
[ Name ]:
Tienilic acid
[Synonym ]:
Tienilic acid
(2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid
Tienilico acido
(2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid
Acidum tienilicum
TienilicAcid
Selacryn
acetic acid, [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-
Diflurex
Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid
[2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid
Acido tienilico
Acide tienilique
2,3-dichloro-4-(thien-2-ylcarbonyl)-phenoxyacetic acid
[2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic acid
[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid
Acetic acid, 2-[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-
Ticrex
{[2,3-dichloro-4-(2-thienylcarbonyl)phenyl]oxy}acetic acid
Ticrynafen
2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid
Thienylic acid
[2,3-dichloro-4-(thiophen-2-ylcarbonyl)phenoxy]acetic acid
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
534.6±50.0 °C at 760 mmHg
[ Melting Point ]:
148-149ºC
[ Molecular Formula ]:
C13H8Cl2O4S
[ Molecular Weight ]:
331.17
[ Flash Point ]:
277.1±30.1 °C
[ Exact Mass ]:
329.952026
[ PSA ]:
91.84000
[ LogP ]:
3.07
[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C
[ Index of Refraction ]:
1.632
[ Storage condition ]:
-20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AG9300000
- CHEMICAL NAME :
- Acetic acid, (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-
- CAS REGISTRY NUMBER :
- 40180-04-9
- BEILSTEIN REFERENCE NO. :
- 1260086
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C13-H8-Cl2-O4-S
- MOLECULAR WEIGHT :
- 331.17
- WISWESSER LINE NOTATION :
- T5SJ BVR BG CG DO1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3571 ug/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 6666 ug/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - urine volume decreased
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1275 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 318 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 225 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3360 mg/kg/28D-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6300 mg/kg/14D-I
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,1,1985
Safety Information
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
AG9300000
[ HS Code ]:
2934999090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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