5-Acetyl-2-hydroxybenzamide

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Names

[ CAS No. ]:
40187-51-7

[ Name ]:
5-Acetyl-2-hydroxybenzamide

[Synonym ]:
EINECS 254-830-5
Benzamide, 5-acetyl-2-hydroxy-
MFCD00049222
5-Acetyl-2-hydroxybenzamide
5-Acetylsalicylamide

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
376.3±32.0 °C at 760 mmHg

[ Melting Point ]:
220-222 °C(lit.)

[ Molecular Formula ]:
C9H9NO3

[ Molecular Weight ]:
179.173

[ Flash Point ]:
181.4±25.1 °C

[ Exact Mass ]:
179.058243

[ PSA ]:
80.39000

[ LogP ]:
1.63

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.598

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU8702280
CHEMICAL NAME :
Benzamide, 5-acetyl-2-hydroxy-
CAS REGISTRY NUMBER :
40187-51-7
BEILSTEIN REFERENCE NO. :
3258263
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H9-N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - tremor
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,39,1990

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CU8702280

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acetyl chloride
  • Salicylamide
  • 2-(aminocarbonyl)phenyl acetate

DownStream

  • 5-(Bromoacetyl)salicylamide
  • 5-(bromoacetyl)-2-(phenylmethoxy)benzamide
  • 5-acetyl-2-(phenylmethoxy)benzamide
  • 5-acetyl-3H-1,3-benzoxazol-2-one

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Acylation of salicylamide to 5-acetylsalicylamide using ionic liquids as dual catalyst and solvent. Chen W, et al.

J. Ind. Eng. Chem. (Amsterdam, Neth.) 16(5) , 800-4, (2010)

New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5-or 6-(3-aryl-2-propenoyl)-2 (3H)-benzoxazolones. Ivanova YB, et al.

Heterocycl. Comm. 19(1) , 23-28, (2013)


More Articles

Related Compounds

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  • 5-acetyl-2-methyl-3,4-diphenylcyclopent-2-en-1-one
  • 5-acetyl-2,4-dihydroxybenzoic acid
  • (5-acetyl-2-ethylsulfanylphenyl) acetate
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  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
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  • 2-{[8,9-Dimethoxy-2-(4-nitrophenyl)-[1,2,4]triazolo[1,5-C]quinazolin-5-YL]sulfanyl}acetonitrile
  • N-{2-oxo-2-[(pyridin-3-ylmethyl)amino]ethyl}-2-(1H-pyrrol-1-yl)-1,3-benzothiazole-6-carboxamide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
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  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
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