2-Hydroxy-3-methylbutyric acid

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Names

[ CAS No. ]:
4026-18-0

[ Name ]:
2-Hydroxy-3-methylbutyric acid

[Synonym ]:
D-Valic acid
D-2-HYDROXY-3-METHYLBUTYRIC ACID
A-hydroxyisovaleric acid
DL-2-Hydroxyisovaleric acid
2-HYDROXY-3-METHYLBU
α-hydroxyisovaleric acid
MFCD00004242
Einecs 223-697-5
UNII:02X1W97FWN
DL-a-hydroxyisovaleric acid
L-2-hydroxyisovaleric acid
2-hydroxy-3-methyl-Butyric acid
2-Oxyisovaleric Acid
2-Hydroxy-3-methylbutanoic acid
DL-2-Hydroxy-3-methylbutanoic acid
2-Hydroxy-3-methylbutyric acid
3-Methyl-2-hydroxybutyric acid
Butanoic acid, 2-hydroxy-3-methyl-
2-Hydroxy-3-methylbutyricAcid
2-Hydroxyisopentanoic acid
2-hydroxy-3-Methyl
(2S)-2-Hydroxy-3-methylbutanoic acid
2-hydroxyisovaleric acid
DL-α-hydroxyisovaleric acid
D-a-Hydroxyisovaleric acid
Butanoic acid, 2-hydroxy-3-methyl-, (2S)-
2-hydroxy-3-methyl butyric acid

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
237.6±13.0 °C at 760 mmHg

[ Melting Point ]:
86-87ºC(lit.)

[ Molecular Formula ]:
C5H10O3

[ Molecular Weight ]:
118.131

[ Flash Point ]:
111.8±16.3 °C

[ Exact Mass ]:
118.062996

[ PSA ]:
57.53000

[ LogP ]:
0.18

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.455

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • trimethyl-(3-methyl-1-trimethylsilyloxybut-1-enoxy)silane
  • α-Ketoisovaleric acid
  • 1,4-Dioxane
  • L-Valine
  • 1-(1H-indolylcarbonyl)-2-methylpropyl (4-methoxyphenyl)acetate
  • 2-bromo-3-methyl-butanamide
  • DL-Valine
  • 3-Methylbutanoic acid
  • Ethyl 2-bromo-3-methylbutyrate

DownStream

  • 2-Hydroxyisobutyric acid
  • acetic acid
  • Acetone
  • isobutanol
  • α-Ketoisovaleric acid
  • Carbon dioxide
  • Isobutyraldehyde
  • Formic Acid
  • tert-butyl 2-hydroxy-3-methylbutanoate

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

α-Ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain

Brain Res. 1324 , 75-84, (2010)

Patients affected by maple syrup urine disease (MSUD) present severe neurological symptoms and brain abnormalities, whose pathoiphysiology is poorly known. In the present study we investigated the in ...

Renal clearance of branched-chain L-amino and 2-oxo acids in maple syrup urine disease.

J. Inherit. Metab. Dis. 22(6) , 706-22, (1999)

In maple syrup urine disease (MSUD), branched-chain L-amino (BCAA) and 2-oxo acids (BCOA) accumulate in body fluids owing to an inherited deficiency of branched-chain 2-oxo acid dehydrogenase complex ...


More Articles

Related Compounds

  • 2-hydroxy-3-methylbutyric acid
  • 2-Hydroxy-3-methylbutyric acid
  • 2-Hydroxy-3-methylbutyric acid
  • 2-Hydroxy-3-methylbutyric acid methyl ester
  • (R)-2-Hydroxy-3-methylbutyric acid benzyl ester
  • (R)-2-Hydroxy-3-methylbutyric acid benzyl ester
  • 5-methyl-1-[2-(oxolan-3-yloxy)ethyl]-1H-pyrazol-3-amine
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-[1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]acetate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[3-(aminomethyl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
  • 1-[4-Methoxy-2-methyl-1-(2-nitrobenzenesulfonyl)pyrrolidin-2-yl]methanamine
  • Dimethyl({[3-(pyrrolidin-3-yl)-1,2,4-oxadiazol-5-yl]methyl})amine
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-N,3-dimethylbutanamido}-2-methylpropanoic acid
  • 5-(1,1,2,2-Tetrafluoroethyl)-1,2-oxazol-3-amine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile