(S) FTY720 Phosphate

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Names

[ CAS No. ]:
402616-26-6

[ Name ]:
(S) FTY720 Phosphate

[Synonym ]:
1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester), (2S)-
(S)-2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol mono(dihydrogenphosphate) ester
(2S)-2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate
FTY720 (S)-Phosphate
fingolimod-P
1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester)
(S)-FTY720-P
2-Amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate
2-(S)-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester
(S)-FTY720
2-ammonio-2-(hydroxymethyl)-4-(4-octylphenyl)butyl hydrogen phosphate
(S)-FTY720-phosphate
[14C]-(S)-FTY720P

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
584.2±60.0 °C at 760 mmHg

[ Melting Point ]:
184-186ºC

[ Molecular Formula ]:
C19H34NO5P

[ Molecular Weight ]:
387.451

[ Flash Point ]:
307.1±32.9 °C

[ Exact Mass ]:
387.217468

[ PSA ]:
122.82000

[ LogP ]:
4.27

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.541

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one
  • (R/S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ5-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one
  • Fingolimod
  • 4-(oct-1-en-1-yl)benzaldehyde
  • 2-methylene-4-(4'-octylphenyl)butanal
  • 2-methylene-4-(4'-octylphenyl)butan-1-ol
  • Heptyl(triphenyl)phosphonium bromide
  • 4-(4-octylphenyl)butan-1-ol
  • N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)acetamide

DownStream

Articles

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Nat. Neurosci. 17(7) , 971-80, (2014)

FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking...


More Articles

Related Compounds

  • fingolimod-P
  • Ethanethiol, 2-amino-,1-(dihydrogen phosphate)
  • fingolimod-P
  • S-8510 phosphate
  • (-)-(S)-Benproperinium dihydrogen phosphate
  • (S)-2,3-dihydroxypropyl dihydrogen phosphate, compound with cyclohexylamine (1:2)
  • 6-Cyano-2, 3-difluorobenzyl alcohol
  • 4-[(2-amino-4-chloro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl]-3-methoxyBenzenemethanol
  • 4-Chloro-N-methyl-N-1H-pyrazol-3-ylbutanamide
  • 2-Chloro-6-(2-nitroethenyl)phenol
  • 6-Chloro-7-methyl((e)-2-nitrovinyl)phenol
  • (e)-2,2-Dimethyl-6-(2-nitrovinyl)chroman
  • 6-Cyclopropyl-8-fluoro-2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinolin-1-one
  • 2-(Pyrrolidin-3-yloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole
  • 5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carbonitrile
  • 1-(4-Hydroxyphenyl)cyclopentane-1-carbonitrile
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