Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide

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Names

[ CAS No. ]:
40277-05-2

[ Name ]:
Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide

[Synonym ]:
4-Hydroxycyclophosphamid
4-Hydroperoxydechlorocyclophosphamide
4-Hydroxycyclophosphamide
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-4-ol
4-OH cyclophosphamide

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
387.1ºC at 760 mmHg

[ Molecular Formula ]:
C7H15Cl2N2O3P

[ Molecular Weight ]:
277.08500

[ Flash Point ]:
187.9ºC

[ Exact Mass ]:
276.02000

[ PSA ]:
71.61000

[ LogP ]:
1.53120

[ Index of Refraction ]:
1.527

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6162000
CHEMICAL NAME :
2H-1,3,2-Oxazaphosphorin-4-ol, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide
CAS REGISTRY NUMBER :
40277-05-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H15-Cl2-N2-O3-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

Safety Information

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

  • 4-(S-Ethanol)-sulfido-cyclophosphamide
  • 2H-1,3,2-Oxazaphosphorin-2-amine,4,4'-dioxybis[N,N-bis(2-chloroethyl)tetrahydro-, 2,2'-dioxide

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 3-Cyclopropyl-5-(3-{[1,2,4]triazolo[4,3-a]pyridin-3-yl}azetidin-1-yl)-1,2,4-thiadiazole
  • 2-[(1-{3-Methyl-[1,2,4]triazolo[4,3-a]pyrazin-8-yl}pyrrolidin-3-yl)methoxy]pyrazine
  • 1-{1-[(3,4-Dichlorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine
  • 2-[3-(4,4-Difluoropiperidine-1-carbonyl)piperidin-1-yl]-4-methanesulfonyl-1,3-benzothiazole
  • 2-[3-(4,4-Difluoropiperidine-1-carbonyl)piperidin-1-yl]-6-methoxy-1,3-benzothiazole
  • 1-{Thieno[2,3-d]pyrimidin-4-yl}-3-{[1,2,4]triazolo[4,3-a]pyridin-3-yl}azetidine
  • 3-(4-Ethynylphenyl)-3-methylbutanoic acid
  • 1-methyl-2-(3-{[1,2,4]triazolo[4,3-a]pyridin-3-yl}azetidin-1-yl)-1H-1,3-benzodiazole
  • 2-(3-Methyl-5-neopentyl-4H-1,2,4-triazol-4-yl)ethan-1-amine
  • (1R)-3-amino-1-{pyrazolo[1,5-a]pyrimidin-6-yl}propan-1-ol
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