Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide

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Names

[ CAS No. ]:
40277-05-2

[ Name ]:
Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide

[Synonym ]:
4-Hydroxycyclophosphamid
4-Hydroperoxydechlorocyclophosphamide
4-Hydroxycyclophosphamide
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-4-ol
4-OH cyclophosphamide

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
387.1ºC at 760 mmHg

[ Molecular Formula ]:
C7H15Cl2N2O3P

[ Molecular Weight ]:
277.08500

[ Flash Point ]:
187.9ºC

[ Exact Mass ]:
276.02000

[ PSA ]:
71.61000

[ LogP ]:
1.53120

[ Index of Refraction ]:
1.527

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6162000
CHEMICAL NAME :
2H-1,3,2-Oxazaphosphorin-4-ol, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide
CAS REGISTRY NUMBER :
40277-05-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H15-Cl2-N2-O3-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

Safety Information

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

  • 4-(S-Ethanol)-sulfido-cyclophosphamide
  • 2H-1,3,2-Oxazaphosphorin-2-amine,4,4'-dioxybis[N,N-bis(2-chloroethyl)tetrahydro-, 2,2'-dioxide

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds

  • N-(4-butoxyphenyl)-4-fluoro-3-methylbenzenesulfonamide
  • N-(4-butoxyphenyl)-5-chloro-2-methoxy-4-methylbenzenesulfonamide
  • (4-Bromo-2-methylphenyl)[(4-ethoxy-2,3-dimethylphenyl)sulfonyl]amine
  • {[3-(Tert-butyl)-4-methoxyphenyl]sulfonyl}(4-bromo-2-methylphenyl)amine
  • Ethyl 4-{[(4-ethoxynaphthyl)sulfonyl]amino}benzoate
  • Ethyl 4-{[(5-ethoxy-2,4-dimethylphenyl)sulfonyl]amino}benzoate
  • Ethyl 4-[2-ethoxy-4-methyl-5-(propan-2-yl)benzenesulfonamido]benzoate
  • Ethyl 4-{[(2,5-dichloro-4-ethoxyphenyl)sulfonyl]amino}benzoate
  • 3-tert-butyl-N-(2-ethoxyphenyl)-4-methoxybenzenesulfonamide
  • 2,5-dichloro-4-ethoxy-N-(2-ethoxyphenyl)benzenesulfonamide
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