Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide

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Names

[ CAS No. ]:
40277-05-2

[ Name ]:
Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide

[Synonym ]:
4-Hydroxycyclophosphamid
4-Hydroperoxydechlorocyclophosphamide
4-Hydroxycyclophosphamide
2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-4-ol
4-OH cyclophosphamide

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
387.1ºC at 760 mmHg

[ Molecular Formula ]:
C7H15Cl2N2O3P

[ Molecular Weight ]:
277.08500

[ Flash Point ]:
187.9ºC

[ Exact Mass ]:
276.02000

[ PSA ]:
71.61000

[ LogP ]:
1.53120

[ Index of Refraction ]:
1.527

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6162000
CHEMICAL NAME :
2H-1,3,2-Oxazaphosphorin-4-ol, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide
CAS REGISTRY NUMBER :
40277-05-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H15-Cl2-N2-O3-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

Safety Information

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

  • 4-(S-Ethanol)-sulfido-cyclophosphamide
  • 2H-1,3,2-Oxazaphosphorin-2-amine,4,4'-dioxybis[N,N-bis(2-chloroethyl)tetrahydro-, 2,2'-dioxide

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-(5-chloro-2-methoxyphenyl)-3-(5-methyl-1H-benzo[d]imidazol-2-yl)azetidine-1-carboxamide
  • Tert-butyl 4-(2-(2-fluorophenyl)acetyl)piperazine-1-carboxylate
  • N-(1-cyanocyclohexyl)-2-[(3-fluorophenyl)formamido]acetamide
  • 2-[(4-cyano-1-ethyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N-(2-ethoxyphenyl)acetamide
  • Bis(propan-2-yl)(2-{[4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}ethyl)amine
  • 2-[(4-cyano-1-methyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N-(2-ethoxyphenyl)acetamide
  • 2-{[4-(4-chlorophenyl)phthalazin-1-yl]sulfanyl}-N-(2-ethoxyphenyl)acetamide
  • N-(2-ethoxyphenyl)-2-{[7-methoxy-4-(trifluoromethyl)quinolin-2-yl]sulfanyl}acetamide
  • 3-Isoquinolinecarboxamide,n-[(1r)-1-[(4-chlorophenyl)methyl]-2-[4-(2,3-dihydro-1h-indol-7-yl)-1-piperazinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-,(3r)-
  • 3-[1-(4-chlorophenyl)-1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl]-1-methylpyrrolidine-2,5-dione
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