4-Fluoro-3-methylbenzoic acid

Names

[ CAS No. ]:
403-15-6

[ Name ]:
4-Fluoro-3-methylbenzoic acid

[Synonym ]:
4-Fluoro-m-toluic acid
Benzoic acid, 4-fluoro-3-methyl-
4-Fluoro-3-methylbenzoic acid
QVR DF C1
MFCD01631424

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
266.3±20.0 °C at 760 mmHg

[ Melting Point ]:
164-168 °C(lit.)

[ Molecular Formula ]:
C₈H₇FO₂

[ Molecular Weight ]:
154.138

[ Flash Point ]:
114.9±21.8 °C

[ Exact Mass ]:
154.043015

[ PSA ]:
37.30000

[ LogP ]:
2.53

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.533

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Carbon dioxide
Bromo(4-fluoro-3-methylphenyl)magnesium
4-Fluorobenzoic acid
methyl iodide
Tert-Butyllithium
1-Fluoro-2,4-dimethylbenzene
2,4-Xylidine
4'-Fluoro-3'-methylacetophenone
4,4'-difluoro-3,3'-dimethyl-biphenyl
2-Fluorotoluene

DownStream

4-Fluoroisophthalic acid
4-Fluoro-3-methylbenzoyl chloride
Methyl 4-Fluoro-3-methylbenzoate
(3-methyl-4-pyrrolidin-1-ylphenyl)-phenylmethanone

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Development of fluorine-18-labeled 5-HT1A antagonists. Lang L, et al.

J. Med. Chem. 42(9) , 1576-1586, (1999)

4-FLUORO-3-METHYLBENZOIC ACID
2-amino-4-fluoro-3-methylbenzoic acid
4-Fluoro-3-methylbenzoic acid chloride
2-chloro-4-fluoro-3-methylbenzoic acid
4-fluoro-3-methylbenzoic acid methyl ester
4-Fluoro-3-methoxy-5-methylbenzoic acid methyl ester
N-(4-(naphthalen-2-yl)thiazol-2-yl)-3-(phenylsulfonyl)propanamide
N-(4-(3,4-dichlorophenyl)thiazol-2-yl)-3-(phenylsulfonyl)propanamide
N-(4-bromo-2-(2-chlorobenzoyl)phenyl)-3-(phenylsulfonyl)propanamide
N-(4-(benzo[d][1,3]dioxol-5-yl)thiazol-2-yl)-3-(phenylsulfonyl)propanamide
N-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)thiazol-2-yl)-3-(phenylsulfonyl)propanamide
N-(3-(benzo[d]thiazol-2-yl)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3-(phenylsulfonyl)propanamide
(2E,6Z)-4-Hydroxy-2,6-dodecadienoic acid
N-(4-(2,4-dichlorophenyl)thiazol-2-yl)-3-(phenylsulfonyl)propanamide
3-(phenylsulfonyl)-N-(4H-thiochromeno[4,3-d]thiazol-2-yl)propanamide
N-(1,3-dioxoisoindolin-5-yl)-4-(N-methyl-N-((tetrahydrofuran-2-yl)methyl)sulfamoyl)benzamide

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