Acetamide, N-(4-chlorophenyl)-2,2,2-trifluoro-

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Names

[ CAS No. ]:
404-25-1

[ Name ]:
Acetamide, N-(4-chlorophenyl)-2,2,2-trifluoro-

[Synonym ]:
p-chloro-N-trifluoroacetylaniline
ACETANILIDE,4'-CHLORO-2,2,2-TRIFLUORO
N-4-chlorophenyltrifluoroacetamide
4'-Chloro-2,2,2-trifluoroacetanilide

Chemical & Physical Properties

[ Density]:
1.482g/cm3

[ Boiling Point ]:
276.4ºC at 760 mmHg

[ Molecular Formula ]:
C8H5ClF3NO

[ Molecular Weight ]:
223.58000

[ Flash Point ]:
121ºC

[ Exact Mass ]:
223.00100

[ PSA ]:
29.10000

[ LogP ]:
2.91380

[ Vapour Pressure ]:
0.00481mmHg at 25°C

[ Index of Refraction ]:
1.52

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AE1845200
CHEMICAL NAME :
Acetanilide, 4'-chloro-2,2,2-trifluoro-
CAS REGISTRY NUMBER :
404-25-1
BEILSTEIN REFERENCE NO. :
2107044
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H5-Cl-F3-N-O
MOLECULAR WEIGHT :
223.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
669 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 39,403,1984

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Chloroaniline
  • Trifluoroacetic anhydride
  • trifluoroacetic acid
  • Sodium perfluoroacetate
  • N-(4-chlorophenyl)-2,2,2-trifluoroacetimidoyl chloride

DownStream

  • 4-chloro-N-prop-2-ynylaniline
  • 4-chloro-N-(2,2,2-trifluoroethyl)aniline
  • 4-chlorophenyl isothiocyanate

Related Compounds

  • Acetamide, N-[(4-chlorophenyl)methyl]-2,2,2-trifluoro
  • N-(2-chloro-4-sulfamoylphenyl)-2,2,2-trifluoroacetamide
  • N-(2-Benzoyl-4-chlorophenyl)-2,2,2-trifluoroacetamide
  • N-(4-Bromo-3-chlorophenyl)-2,2,2-trifluoroacetamide
  • Acetamide, N-(4-ethynylphenyl)-2,2,2-trifluoro-
  • Acetamide, N-(4-cyanophenyl)-2,2,2-trifluoro-
  • N-[(5-bromo-2-pyridinyl)methyl]-6-methyl-2-pyridinecarboxamide
  • US10246456, Example 75
  • 6-(6-Acetyl-2-pyridinyl)-2-(6-methyl-2-pyridinyl)-2H-indazole-4-carbonitrile
  • 2-Chloro-8-methyl-5,6,7,8-tetrahydroquinolin-8-ol
  • (6-(6-(4-Methoxybenzyloxy)-4-bromo-1h-indazol-1-yl)pyridin-2-yl)methanol
  • 2-Chloro-5,6,7,8-tetrahydroquinoline 1-oxide
  • N-(2,4-dimethoxybenzyl)-5-isopropylpyridazin-3-amine
  • Methyl 6-(6-bromo-1h-indazol-1-yl)pyridine-2-carboxylate
  • 1-(6-Bromo-2-pyridinyl)-2-methoxy-1-butanone
  • 6-Bromo-5-methyl-1-(6-methyl-2-pyridinyl)-1h-indazole