(2-Iodophenyl)acetonitrile

Names

[ Name ]:
(2-Iodophenyl)acetonitrile

[Synonym ]:
Benzeneacetonitrile, 2-iodo-
2-(2-iodophenyl)acetonitrile
(2-Iodophenyl)acetonitrile
MFCD00040888
2-IODOPHENYLACETONITRILE

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
306.0±17.0 °C at 760 mmHg

[ Melting Point ]:
24 - 30 °C

[ Molecular Formula ]:
C₈H₆IN

[ Molecular Weight ]:
243.044

[ Flash Point ]:
138.8±20.9 °C

[ Exact Mass ]:
242.954483

[ PSA ]:
23.79000

[ LogP ]:
2.48

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.624

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S23-S26-S36

[ RIDADR ]:
3276

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

POTASSIUM CYANIDE
2-Iodobenzyl chloride
α-Bromo-2-iodotoluene
Sodium cyanide
(2-Iodophenyl)methanol
sodium cyanide
N,N-Dimethylformamide
2-iodobenzyl iodide
4-Iodotoluene

DownStream

Benzyl cyanide
(2-CHLOROPHENYL)PHENYL-METHANONE
6H-DIBENZ[B,D]AZEPIN-6-ONE, 7-AMINO-5,7-DIHYDRO-5-METHYL-
Oxindole
2-(2-Iodophenyl)ethan-1-ol
5H,7H-Dibenzo[b,d]azepin-6-one
Phenindione
6H-DIBENZ[B,D]AZEPIN-6-ONE, 5,7-DIHYDRO-5-METHYL-
2-Iodophenylacetic acid
2-(2-Chlorophenyl)ethanol

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Palladium(II)-Catalyzed Annulation of Alkynes with 2-(Cyanomethyl)phenylboronates Leading to 3,4-Disubstituted 2-Naphthalenamines.

J. Org. Chem. 81(5) , 1733-45, (2016)

1,2-Bis(diphenylphosphino)ethane (dppe)-ligated palladium(II) complexes catalyze the annulation of internal alkynes with 2-(cyanomethyl)phenylboronates to provide 3,4-disubstituted-2-naphthalenamines ...

4,6-O-[1-cyano-2-(2-iodophenyl)ethylidene] acetals. improved second-generation acetals for the stereoselective formation of beta-D-mannopyranosides and regioselective reductive radical fragmentation to beta-D-rhamnopyranosides. scope and limitations.

J. Org. Chem. 71(9) , 3452-63, (2006)

The [1-cyano-2-(2-iodophenyl)]ethylidene group is introduced as an acetal-protecting group for carbohydrate thioglycoside donors. The group is easily introduced under mild conditions, over short react...

Palladium-catalyzed carboxamidation reaction and aldol condensation reaction cascade: A facile approach to ring-fused isoquinolinones. Chouhan G and Alper H.

Org. Lett. 10(21) , 4987-4990, (2008)

2-hydroxy-2-(2-iodophenyl)acetonitrile
4-BROMO-2-IODOPHENYLACETONITRILE
(2-Chloro-5-iodophenyl)acetonitrile
(2-Amino-5-iodophenyl)acetonitrile
2-(3-Fluoro-4-iodophenyl)acetonitrile
(2-iodophenyl)phenylmethanol
1-(3,4-Dimethylphenyl)-1-oxopropan-2-yl 6-chloropyridine-3-carboxylate
(4-(3,3,3-Trifluoropropyl)phenyl)methanamine
N-(1-cyanocyclohexyl)-2-{[4-(morpholin-4-yl)phenyl]amino}propanamide
1-Amino-1,2,3,4-tetrahydronaphthalene-2-carbonitrile
N-[1-(3,4-Dihydro-2H-1,5-benzodioxepin-7-YL)-2-methylpropyl]-2-(methylsulfanyl)pyridine-3-carboxamide
Ethyl 2-(2-Iodophenyl)thiazole-4-carboxylate
2,6-difluoro-N-[3-methyl-1-oxo-1-(4-pyrimidin-2-ylpiperazin-1-yl)butan-2-yl]benzamide
(R)-3-Allylmorpholine
3-(2-chlorophenyl)-N-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]-N-(furan-2-ylmethyl)-5-methyl-1,2-oxazole-4-carboxamide
1-[(1-Cyanocyclohexyl)carbamoyl]ethyl 5-chloro-2-nitrobenzoate

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