nidroxyzone

Suppliers

Names

[ CAS No. ]:
405-22-1

[ Name ]:
nidroxyzone

[Synonym ]:
Furadroxyl
Fradroxyl
5-Nitro-furaldehyd-2-<(2-hydroxy-ethyl)-semicarbazon>
nidroxyzone
5-Nitro-2-furaldehyde 2-(2-hydroxyethyl)semicarbazone
5-nitro-furfural-[2-(2-hydroxy-ethyl)-semicarbazone]
5-Nitro-furfural-[2-(2-hydroxy-aethyl)-semicarbazon]

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Boiling Point ]:
453.2ºC at 760mmHg

[ Melting Point ]:
214-216° (dec)

[ Molecular Formula ]:
C8H10N4O5

[ Molecular Weight ]:
242.18900

[ Flash Point ]:
227.9ºC

[ Exact Mass ]:
242.06500

[ PSA ]:
137.88000

[ LogP ]:
1.11820

[ Vapour Pressure ]:
5.29E-09mmHg at 25°C

[ Index of Refraction ]:
1.639

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LT7400000
CHEMICAL NAME :
2-Furaldehyde, 5-nitro-, 2-(2-hydroxyethyl)semicarbazone
CAS REGISTRY NUMBER :
405-22-1
BEILSTEIN REFERENCE NO. :
0269535
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C8-H10-N4-O5
MOLECULAR WEIGHT :
242.22
WISWESSER LINE NOTATION :
T50J BNW E1UNNVZ2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,313,1950
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 3,429,1953 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1800 mg/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 112,367,1952
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1800 mg/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 56,727,1955
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3360 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 69,331,1961
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5520 mg/kg
SEX/DURATION :
female 23 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 69,331,1961
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1200 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 69,331,1961
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2520 mg/kg
SEX/DURATION :
male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 69,331,1961

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Precursor & DownStream

Precursor

  • 5-Nitrofuraldehyde
  • 2-Hydrazinoethanol

DownStream

  • Furazolidone
  • 3-Oxazolidinamine,2-imino-N-[(5-nitro-2-furanyl)methylene]-

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds

  • 4-{[(4-Ethoxyphenyl)(methylsulfonyl)amino]methyl}benzoic acid
  • |A-Cyano-2,3,4,5,6-pentafluorocinnamic acid
  • N-[1-Oxo-4-(phenylthio)butyl]glycine
  • 1,1':3',1''-Terphenyl, 2'-iodo-2,2''-dimethyl-
  • Methyl (3E)-4-(3-bromophenyl)-2-oxobut-3-enoate
  • 5-(2-Bromophenyl)-N-ethyl-2-thiophenemethanamine
  • 2-amino-N-methyl-6-propyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
  • 2-Methyl-4-[5-(trifluoromethyl)-2-benzothiazolyl]benzenamine
  • N-(2-methoxy-5-methylphenyl)-2-(thiophen-2-ylsulfonyl)acetamide
  • N-(4-chlorobenzyl)-N-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)pyridine-3-sulfonamide
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