2-nitrosooxazinane

Names

[ CAS No. ]:
40548-68-3

[ Name ]:
2-nitrosooxazinane

[Synonym ]:
2H-1,2-Oxazine,2-nitrosotetrahydro
N-nitrosotetrahydro-1,2-oxazine
2-Nitrosotetrahydro-1,2-oxazine
N-Nitrosotetrahydro-1,2-oxazin
2H-1,2-Oxazine,tetrahydro-2-nitroso
Tetrahydro-2-nitroso-2H-1,2-oxazine
2-nitroso-1,2-oxazinane

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
127.3ºC at 760 mmHg

[ Molecular Formula ]:
C4H8N2O2

[ Molecular Weight ]:
116.11900

[ Flash Point ]:
30.8ºC

[ Exact Mass ]:
116.05900

[ PSA ]:
41.90000

[ LogP ]:
0.63310

[ Index of Refraction ]:
1.546

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP6430000
CHEMICAL NAME :
2H-1,2-Oxazine, tetrahydro-2-nitroso-
CAS REGISTRY NUMBER :
40548-68-3
BEILSTEIN REFERENCE NO. :
0112124
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C4-H8-N2-O2
MOLECULAR WEIGHT :
116.14
WISWESSER LINE NOTATION :
T6NOTJ ANO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
830 mg/kg
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Liver - hepatitis (hepatocellular necrosis), zonal Blood - hemorrhage
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 79,114,1973 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18 gm/kg/63W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 79,114,1973

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2-Oxazinane hydrochloride
  • [1,2]Oxazinane

DownStream

  • Butanol

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)aniline
  • 2-((4-(1-METHYL-4-(PYRIDIN-4-YL)-1H-PYRAZOL-3-YL)PHENOXY)METHYL)QUINOLINE SUCCINATE
  • 2-[(4-aminobenzoyl)-benzylamino]ethyl-diethylazanium,chloride
  • 2-(Dimethylphosphoryl)aniline
  • 2-(3-Chloropropoxy)-1-methoxy-4-nitrobenzene
  • 2(1H)-Pyrimidinone,6-amino-5-nitro-
  • 2-Benzyl-6-(3,4-dimethylphenyl)-4-methyl-4a,7,8,9a-tetrahydropurino[7,8-a]imidazole-1,3-dione
  • 9-(4-chlorophenyl)-3-[(2-chlorophenyl)methyl]-1-methyl-6,7,8,9a,10,10a-hexahydro-4aH-purino[7,8-a]pyrimidine-2,4-dione
  • 1-methyl-3-[(4-methylphenyl)methyl]-9-phenyl-6,7,8,9a,10,10a-hexahydro-4aH-purino[7,8-a]pyrimidine-2,4-dione
  • tert-Butyl 4-(3-((3-(cyclopropylamino)quinoxalin-2-yl)oxy)propyl)piperidine-1-carboxylate
  • 4-Cyclopropoxy-3-isopropoxypicolinonitrile
  • 1H-1,2,4-Triazole-5-methanol, 3-(3-chlorophenyl)-
  • 1-(3-Chloro-4,5-dimethoxyphenyl)ethan-1-amine
  • (1R)-1-(1-phenylcyclopentyl)ethan-1-amine
  • (1S)-1-{7-oxabicyclo[2.2.1]heptan-2-yl}ethan-1-amine
  • 1H-1,2,4-Triazole-5-methanol, 3-(4-methylphenyl)-