MITOMYCIN B

Names

[ CAS No. ]:
4055-40-7

[ Name ]:
MITOMYCIN B

[Synonym ]:
Mitomycin B 0nnDiscontinued
Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione,1,1a,2,8,8a,8b-hexahydro-8a-hydroxy-8-(hydroxymethyl)-6-methoxy-1,5-dimethyl-,8-carbamate
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-hydroxy-6-methoxy-1,5-dimethyl-, (1aS,8R,8aR,8bS)-
MITOMYCIN B
[(1aS,8R,8aR,8bS)-8a-Hydroxy-6-methoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate
CID4209

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
606.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H19N3O6

[ Molecular Weight ]:
349.339

[ Flash Point ]:
320.6±31.5 °C

[ Exact Mass ]:
349.127380

[ PSA ]:
122.17000

[ LogP ]:
0.98

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.675

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CN0875000
CAS REGISTRY NUMBER :
4055-40-7
LAST UPDATED :
199806
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C16-H19-N3-O6
MOLECULAR WEIGHT :
349.38
WISWESSER LINE NOTATION :
T D3 B556 BN EN JV MVTTT&J E1 GQ H1OVZ KO1 L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
60 umol/L
REFERENCE :
CJBIAE Canadian Journal of Biochemistry. (Ontario, Canada) V.42-60, 1964-82. For publisher information, see CJBBDU. Volume(issue)/page/year: 56,296,1978

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

  • 8-(Aminocarbonyloxymethyl)-1,1a,2,8b-tetrahydro-6-methoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
  • Mitomycin D
  • 7-amino-10-decarbamoyloxy-9-dehydro-7-demethoxymitomycin B

Related Compounds

  • 9-Epimitomycin B
  • 9-epi-mitomycin B
  • 9a-O-Methylmitomycin B
  • mitiromycin
  • Benzenepropanamide, b-oxo-N-phenyl-
  • Antifoam B
  • Benzenemethanaminium, N-ethyl-N-[4-[[4-[ethyl[(4-sulfophenyl)methyl]amino]phenyl]phenylmethylene]-2,5-cyclohexadien-1-ylidene]-4-sulfo-, inner salt
  • 4-(2-Propen-1-yl)-1-propyl-4-piperidinol
  • N-(2,4-bis(dimethylamino)pyrimidin-5-yl)nicotinamide
  • N-(2,4-bis(dimethylamino)pyrimidin-5-yl)-4-(pyrimidin-2-yloxy)benzamide
  • 1-(2,4-Bis(dimethylamino)pyrimidin-5-yl)-3-(2-chlorophenyl)urea
  • 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-(2,4,6-trimethylphenyl)acetic acid
  • 2-[(E)-3-chloroprop-1-enyl]imidazo[1,2-a]pyridine
  • 4-(2-oxo-2-(1H-pyrrol-2-yl)ethyl)piperazine-2-carboxylic acid
  • 4-(2-tert-Butoxycarbonylamino-ethoxy)-2-methyl-benzoic acid
  • tert-Butyl ((1-(aminomethyl)cyclobutyl)methyl)carbamate
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