SB590885

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Names

[ CAS No. ]:
405554-55-4

[ Name ]:
SB590885

[Synonym ]:
N-{5-[2-{4-[2-(dimethylamino)ethoxy]phenyl}-4-(pyridin-4-yl)-1H-imidazol-5-yl]-2,3-dihydro-1H-inden-1-ylidene}hydroxylamine
1H-Inden-1-one, 5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-, oxime, (1Z)-
(E)-SB-590885
2-(4-{4-[(1Z)-1-(Hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(4-pyridinyl)-1H-imidazol-2-yl}phenoxy)-N,N-dimethylethanamine
1H-Inden-1-one, 5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-, oxime, (1E)-
2-(4-{4-[1-(Hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(4-pyridinyl)-1H-imidazol-2-yl}phenoxy)-N,N-dimethylethanamine
2-(4-{4-[(1E)-1-(Hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-5-(4-pyridinyl)-1H-imidazol-2-yl}phenoxy)-N,N-dimethylethanamine
5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1h-imidazol-4-yl]-2,3-dihydro-1h-inden-1-on
SB-590885

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
691.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H27N5O2

[ Molecular Weight ]:
453.536

[ Flash Point ]:
371.8±31.5 °C

[ Exact Mass ]:
453.216461

[ PSA ]:
86.63000

[ LogP ]:
5.01

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.666

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble2mg/mL (clear solution, warmed)

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

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Oncogenesis 3 , e110, (2014)

Melanoma is curable when it is at an early phase but is lethal once it becomes metastatic. The recent development of BRAF(V600E) inhibitors (BIs) showed great promise in treating metastatic melanoma, ...


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Related Compounds

  • SB-200646A
  • SB-269970
  • SB-668875
  • SB 612111-d4 hydrochloride
  • SB-408124 Hydrochloride
  • SB 243213 hydrochloride
  • 3-Iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-6-carbonitrile
  • Benzeneacetic acid, 3-cyano-2-(trifluoromethyl)-6-[(trifluoromethyl)thio]-, methyl ester
  • 1,7-Naphthyridin-2(1H)-one, 4-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropyl]methylamino]-
  • 2,2a(2),2a(2)a(2)-[(Hexahydro-1H-1,4,7-triazonine-1,4,7-triyl)tris(sulfonyl)]tris[4-methylphenol]
  • 1H-Pyrazolo[3,4-c]pyridine-1-carboxylic acid, 3-(2-bromoethyl)-, 1,1-dimethylethyl ester
  • Ethyl 1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-1,2,3-triazole-4-carboxylate
  • 3-Isoxazolecarboxylic acid, 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2,5-dihydro-
  • 2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl I+/--bromobenzenepropanoate
  • [3-(2,4-Difluoro-6-methoxyphenyl)-2,2-dimethylcyclopropyl]methanamine
  • 1,3-Piperidinedicarboxylic acid, 4-fluoro-3-methyl-, 1-(1,1-dimethylethyl) 3-ethyl ester