1-Chloro-2-methyl-1-oxopropan-2-yl acetate

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Names

[ Name ]:
1-Chloro-2-methyl-1-oxopropan-2-yl acetate

[Synonym ]:
2-acetoxyisobutyryl chloride (α-acetoxy-isobutyryl chloride)
Acetic acid, 1-chlorocarbonyl-1-methylethyl ester
2-Acetoxyisobutyryl Chloride
1-Chloro-2-methyl-1-oxo-2-propanyl acetate
2-Acetoxy-2-methylpropionyl Chloride
(1-chloro-2-methyl-1-oxopropan-2-yl) acetate
1-Chloro-2-methyl-1-oxopropan-2-yl acetate
Chlorocarbonyl-1-methylethyl acetate
2-Chloro-1,1-dimethyl-2-oxoethyl acetate
Propanoyl chloride, 2-(acetyloxy)-2-methyl-
MFCD00000708
EINECS 255-016-2

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
178.8±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₉ClO₃

[ Molecular Weight ]:
164.587

[ Flash Point ]:
68.3±0.0 °C

[ Exact Mass ]:
164.024017

[ PSA ]:
43.37000

[ LogP ]:
1.25

[ Vapour Pressure ]:
1.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.435

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R14;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Propanoic acid,2-(acetyloxy)-2-methyl-
2-Hydroxyisobutyric acid
Acetyl chloride
Ethanoic anhydride

DownStream

α-Acetoxy-isobutyryl bromide
2',5'-dimethylacetophenone
1-Propanone,2-(acetyloxy)-2-methyl-1-phenyl-
(2-methyl-3-oxo-5-phenylpent-4-yn-2-yl) acetate
phenyl 2-acetyloxy-2-methyl-propanoate
Propanoic acid,2-(acetyloxy)-2-methyl-, ethyl ester

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Efficient synthesis of some dichloroalditols: direct regioselective chlorination of some unprotected alditols by 1-chlorocarbonyl-1-methylethyl acetate. Benazza M, et al.

J. Carbohydr. Chem. 13(7) , 967-79, (1994)

Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis.

J. Am. Chem. Soc. 129(1) , 68-76, (2007)

A diastereoselective synthesis of the nucleoside adducts corresponding to a cis ring-opening of the carcinogen (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene ...

(1-chloro-2-methyl-1-oxobutan-2-yl) acetate
(1-acetamido-2-methyl-1-oxopropan-2-yl) acetate
[1-(tert-butylamino)-2-methyl-1-oxopropan-2-yl] acetate
(1-amino-2-methyl-1-oxopropan-2-yl)oxy-methylphosphinate
(1-amino-2-methyl-1-oxopropan-2-yl) hydrogen sulfate,sulfuric acid
1-(benzylamino)-2-methyl-1-oxopropan-2-yl 2-bromo-2-methylpropanoate
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
N-[4,5-Dihydro-4-(4-methoxyphenyl)-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-2,2,2-trifluoroacetamide
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide