Rifamycin SV, 8-(diethylaminomethyl)-

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Names

[ CAS No. ]:
4075-41-6

[ Name ]:
Rifamycin SV, 8-(diethylaminomethyl)-

[Synonym ]:
PF-42
Rifamycin,3-[(diethylamino)methyl]
Rifamycin SV,8-(diethylaminomethyl)
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione,5,6,9,17,19,21-hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy-8-(diethylaminomethyl)-,21-acetate
3-(diethylamino-methyl)-rifamycin
3-Diethylaminomethyl rifamycin SV
NCI 145-666
3-Diaethylaminomethyl-rifamycin SV

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
877.6ºC at 760 mmHg

[ Molecular Formula ]:
C42H58N2O12

[ Molecular Weight ]:
782.91600

[ Flash Point ]:
484.5ºC

[ Exact Mass ]:
782.39900

[ PSA ]:
204.55000

[ LogP ]:
5.73390

[ Index of Refraction ]:
1.618

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KD1920250
CHEMICAL NAME :
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21- hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy -8-(diethylaminomethy l)-, 21-acetate
CAS REGISTRY NUMBER :
4075-41-6
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C42-H58-N2-O12
MOLECULAR WEIGHT :
783.02

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
205 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977

Related Compounds

  • Rifamycin SV,8-(3-methylpiperidinomethyl)
  • 2-benzyl-8-(diethylaminomethyl)-7-methoxy-3-methylchromen-4-one,hydrochloride
  • 25-Deacetyl 3-diethylaminomethyl rifamycin SV
  • ethyl 8-(diethylaminomethyl)-7-hydroxy-4-oxochromene-2-carboxylate,hydrochloride
  • Rifamycin
  • 3-(3-Methoxybutoxyiminomethyl)rifamycin SV
  • 6-(chloromethyl)-N,N-dimethylpyrimidin-4-amine
  • N-Cyclopropyl-I(2)-methylenebenzeneethanamine
  • rac-(1R,2R)-1-amino-2-methylcyclopropane-1-carboxylic acid
  • (2Z)-6-bromo-2-[(4-fluorophenyl)imino]-2H-chromene-3-carboxamide
  • 4-(2-Methoxy-ethoxy)-but-2-ynoic acid
  • 2-Ethyl-5-(furan-2-yl(4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol
  • N-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(thiophen-2-yl)ethyl)-2-phenoxyacetamide
  • 3-(4,6-Dimethylpyrimidin-2-yl)prop-2-yn-1-ol
  • 3-(Oxan-4-yloxy)propanoic acid
  • N-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]-4-methoxybenzenesulfonamide
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