piperaquine phosphate

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Names

[ CAS No. ]:
4085-31-8

[ Name ]:
piperaquine phosphate

[Synonym ]:
Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-
4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline)
Piperaquine tetraphosphate tetrahydrate
7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline
Piperaquine
piperaquinoline
PIRERAQUINE PHOSPHATE
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
721.1±60.0 °C at 760 mmHg

[ Melting Point ]:
198-200°C (lit.)

[ Molecular Formula ]:
C29H32Cl2N6

[ Molecular Weight ]:
535.511

[ Flash Point ]:
389.9±32.9 °C

[ Exact Mass ]:
534.206543

[ PSA ]:
38.74000

[ LogP ]:
5.15

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.664

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC3280000
CHEMICAL NAME :
Quinoline, 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-
CAS REGISTRY NUMBER :
4085-31-8
BEILSTEIN REFERENCE NO. :
0905079
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C29-H32-Cl2-N6
MOLECULAR WEIGHT :
535.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1098 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,273,1986

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

  • 1,3-Dibromopropane
  • 7-Chloro-4-(piperazin-1-yl)quinoline
  • 4,7-Dichloroquinoline

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Piperaquine phosphate
  • Piperaquine phosphate hydrate
  • Dihydroartemisinin / piperaquine phosphate
  • Piperaquine-d6
  • Piperaquine N-Oxide
  • Piperaquine
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  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 1-Fluoro-3-[(thian-4-yl)amino]propan-2-ol
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  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
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  • 3-(1-methyl-1H-indol-2-yl)-2-oxopropanoic acid