2-chloro-n-methylacetoacetamide

Names

[ CAS No. ]:
4116-10-3

[ Name ]:
2-chloro-n-methylacetoacetamide

[Synonym ]:
EINECS 223-907-5
N-methyl-2-chloroacetoacetamide
2-chloro-N-methyl-3-oxobutaneamide
2-Chloro-N-methylacetoacetamide
2-Chlor-acetoessigsaeure-methylamid
2-chloroacetoacetic acid monomethyl amide
Butanamide,2-chloro-N-methyl-3-oxo
Acetoacetamide,2-chloro-N-ethyl
2-Chloro-N-methyl-3-oxobutyramide

Chemical & Physical Properties

[ Density]:
1.188g/cm3

[ Boiling Point ]:
284.1ºC at 760mmHg

[ Melting Point ]:
78-80ºC

[ Molecular Formula ]:
C5H8ClNO2

[ Molecular Weight ]:
149.57600

[ Flash Point ]:
125.6ºC

[ Exact Mass ]:
149.02400

[ PSA ]:
46.17000

[ LogP ]:
0.31970

[ Index of Refraction ]:
1.447

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AK3910000
CHEMICAL NAME :
Acetoacetamide, 2-chloro-N-ethyl-
CAS REGISTRY NUMBER :
4116-10-3
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C5-H8-Cl-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 18,316,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 18,316,1960

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-28-36/37/39-45

[ RIDADR ]:
UN 2923

[ RTECS ]:
AK3910000

[ Packaging Group ]:
III

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-chloro-3-oxobutanoyl chloride
  • methylamine

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]phenyl]acetamide
  • 2-chloro-N-[3-[(2-chloroacetyl)amino]phenyl]acetamide
  • 2-CHLORO-N-CYCLOHEX-1-EN-1-YL-N-ETHYLACETAMIDE
  • 2-chloro-N,N-bis(trimethylsilyl)ethanamine
  • 2-Chloro-N-(3-methoxy-phenyl)-2-phenyl-acetamide
  • 2-Chloro-N-(9,10-dioxo-9,10-dihydro-anthracen-2-yl)-acetamide
  • 1-(3-Methyl-2-pyridyl)-2-pyrrolidinone
  • 4-Cyclopropoxy-2-ethyl-N,N-dimethylnicotinamide
  • 6-chloro-N-ethyl-5-methyl-N-[(4-methylphenyl)(pyridin-3-yl)methyl]pyridine-3-sulfonamide
  • tert-Butyl 2-((benzo[d]isothiazol-3-yloxy)methyl)pyrrolidine-1-carboxylate
  • 2-(Chloromethyl)-3-ethylpyridine
  • tert-Butyl 2-((pyridin-2-ylmethoxy)methyl)pyrrolidine-1-carboxylate
  • 2-Tert-butyl-4-cyclopropoxy-N-methylbenzamide
  • tert-Butyl 2-((pyrazin-2-ylmethoxy)methyl)pyrrolidine-1-carboxylate
  • 1-(4-Bromophenyl)-4-phenyl-1H-1,2,3-triazole
  • N-(1-cyanocyclopentyl)-2-[(3-oxobutan-2-yl)sulfanyl]acetamide
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