2-chloro-n-methylacetoacetamide

Names

[ CAS No. ]:
4116-10-3

[ Name ]:
2-chloro-n-methylacetoacetamide

[Synonym ]:
EINECS 223-907-5
N-methyl-2-chloroacetoacetamide
2-chloro-N-methyl-3-oxobutaneamide
2-Chloro-N-methylacetoacetamide
2-Chlor-acetoessigsaeure-methylamid
2-chloroacetoacetic acid monomethyl amide
Butanamide,2-chloro-N-methyl-3-oxo
Acetoacetamide,2-chloro-N-ethyl
2-Chloro-N-methyl-3-oxobutyramide

Chemical & Physical Properties

[ Density]:
1.188g/cm3

[ Boiling Point ]:
284.1ºC at 760mmHg

[ Melting Point ]:
78-80ºC

[ Molecular Formula ]:
C5H8ClNO2

[ Molecular Weight ]:
149.57600

[ Flash Point ]:
125.6ºC

[ Exact Mass ]:
149.02400

[ PSA ]:
46.17000

[ LogP ]:
0.31970

[ Index of Refraction ]:
1.447

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AK3910000
CHEMICAL NAME :
Acetoacetamide, 2-chloro-N-ethyl-
CAS REGISTRY NUMBER :
4116-10-3
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C5-H8-Cl-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 18,316,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 18,316,1960

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-28-36/37/39-45

[ RIDADR ]:
UN 2923

[ RTECS ]:
AK3910000

[ Packaging Group ]:
III

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-chloro-3-oxobutanoyl chloride
  • methylamine

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]phenyl]acetamide
  • 2-chloro-N-[3-[(2-chloroacetyl)amino]phenyl]acetamide
  • 2-CHLORO-N-CYCLOHEX-1-EN-1-YL-N-ETHYLACETAMIDE
  • 2-chloro-N,N-bis(trimethylsilyl)ethanamine
  • 2-Chloro-N-(3-methoxy-phenyl)-2-phenyl-acetamide
  • 2-Chloro-N-(9,10-dioxo-9,10-dihydro-anthracen-2-yl)-acetamide
  • methyl 2-((1-(4-chlorobenzyl)-7-ethyl-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)thio)acetate
  • 4-(Methoxymethyl)-N-[2-methyl-5-(1-piperidinylsulfonyl)phenyl]benzamide
  • 6-cyclopropyl-N-(2,4-dimethoxyphenyl)-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
  • 3-cyclopropyl-N-(2,4-dimethoxyphenyl)-1-phenyl-1H-pyrazole-5-carboxamide
  • 2-({5-Chloro-4-[(4-methylphenyl)sulfonyl]-1,3-thiazol-2-yl}sulfanyl)ethanol
  • 2-((5-chloro-4-tosylthiazol-2-yl)sulfonyl)-N-(p-tolyl)acetamide
  • N-(4-acetylphenyl)-3-bromopropanamide
  • 3-cyclopropyl-N-(2-methoxyphenyl)-1-phenyl-1H-pyrazole-5-carboxamide
  • N-(3-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-2-carbothioamide
  • (E)-3-(7-chloro-2,3-dihydro-[1,4]dioxino[2,3-g]quinolin-8-yl)-1-cyclopropylprop-2-en-1-one
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