TIC10 Analogue

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Names

[ Name ]:
TIC10 Analogue

[Synonym ]:
Imidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one, 2,6,7,8,9,10-hexahydro-10-[(2-methylphenyl)methyl]-7-(phenylmethyl)-
Potent Akt/ERK inhibitor
7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one
7-Benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one
TIC10 - Isomer
TIC10 isomer

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
559.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₆N₄O

[ Molecular Weight ]:
386.489

[ Flash Point ]:
292.3±32.9 °C

[ Exact Mass ]:
386.210663

[ PSA ]:
42.53000

[ LogP ]:
3.19

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.672

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble2mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL.

Angew. Chem. Int. Ed. Engl. , doi:10.1002/anie.201402133, (2014)

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an immunosurveillance cytokine that kills cancer cells but demonstrates little toxicity against normal cells. While investigati...

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