Spiro[4-azabicyclo[2.2.2]octane-2,2'-oxirane]

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Names

[ CAS No. ]:
41353-91-7

[ Name ]:
Spiro[4-azabicyclo[2.2.2]octane-2,2'-oxirane]

[Synonym ]:
3-methylenequiniclidine epoxide
3-methylenequinuclidine epoxide
Spiro-1-azabicyclo[2.2.2]octan-3-oxirane
Spiro[4-azabicyclo[2.2.2]octane-2,2'-oxirane]
Spiro[1-azabicyclo[2.2.2]octane-3,2'-oxirane]
spiro[1-aza-bicyclo[2.2.2]octane-3,2'-oxirane]
3-methylenequinuclidine oxide

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
211.3±13.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H13NO

[ Molecular Weight ]:
139.195

[ Flash Point ]:
60.4±22.2 °C

[ Exact Mass ]:
139.099716

[ PSA ]:
15.77000

[ LogP ]:
0.83

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.564

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-QUINUCLIDINONE
  • Trimethylsulfoxonium iodide
  • 3-Quinuclidinone hydrochloride

DownStream

  • 1-Azabicyclo[2.2.2]octan-3-ol,3-(mercaptomethyl)-
  • 2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane](Hydrochloride)
  • Cevimeline hydrochloride hemihydrate
  • 3-Hydroxy-1-azabicyclo[2.2.2]octane-3-Methanol

Related Compounds

  • spiro[4-azabicyclo[2.2.2]octane-2,2'-oxirane] chlorhydrate (1:1)
  • Trihydrido(spiro[4-azabicyclo[2.2.2]octane-2,2'-oxirane]-κN)boro
  • Spiro[1-azabicyclo[2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridine], (2'R)-
  • 2'H-Spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazolidin]-2'-one hydrochloride (1:1)
  • AR-R17779 hydrochloride
  • Spiro[1-azabicyclo[2.2.2]octane-3,5-oxazolidine]-2,4-dione (9CI)